Results 31 to 40 of about 3,182 (158)
The SH protein of mumps virus is a druggable pentameric viroporin. [PDF]
Sci AdvViral infections are on the rise and drugs targeting viral proteins are needed. Viroporins constitute a growing group of virus-encoded transmembrane oligomeric proteins that allow passage of small molecules across the membrane.
Devantier K +15 more
europepmc +6 more sources
Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds [PDF]
Chemistry of Heterocyclic Compounds, 2020 Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new inhibitors. In this review, we analyze the data published over the last 10 years on known ion channels of viruses that cause socially ...
Shiryaev, Vadim A., Klimochkin, Yuri N.
openaire +2 more sources
Ebola Virus Delta Peptide Is a Viroporin [PDF]
Journal of Virology, 2017 ABSTRACT The Ebola virus (EBOV) genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, that is produced in abundance during Ebola virus disease (EVD). The function of the delta peptide is unknown, but sequence analysis has suggested that delta peptide could be a viroporin, belonging to a diverse ...
Jing, He +11 more
openaire +2 more sources
Viroporin-mediated calcium-activated autophagy [PDF]
Autophagy, 2013 Autophagy is a cellular response activated by many pathogens, but the mechanism of activation is largely unknown. Recently we showed for the first time that rotavirus initiates the autophagy pathway through a calcium-mediated mechanism. Expression of the rotavirus-encoded NSP4, a pore-forming protein (viroporin), elicits the release of endoplasmic ...
Sue E, Crawford, Mary K, Estes
openaire +2 more sources
Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin?
mSphere, 2020 The simian polyomavirus SV40 was reported to express Vp4, an N-terminally truncated form of the minor capsid proteins Vp2 and Vp3. Since a missense mutation of the putative Vp4 start codon (Vp2M228I) was found to give reduced progeny release and delayed ...
Stian Henriksen +1 more
doaj +1 more source
Scientific Reports, 2023 SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam +4 more
doaj +1 more source
The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.
PLoS ONE, 2011 Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl +6 more
doaj +1 more source
Viruses, 2021 ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Tyng Hwey Tan +5 more
doaj +1 more source
Pathophysiological Consequences of Calcium-Conducting Viroporins [PDF]
Annual Review of Virology, 2015 Eukaryotic cells have evolved a myriad of ion channels, transporters, and pumps to maintain and regulate transmembrane ion gradients. As intracellular parasites, viruses also have evolved ion channel proteins, called viroporins, which disrupt normal ionic homeostasis to promote viral replication and pathogenesis.
Joseph M, Hyser, Mary K, Estes
openaire +2 more sources
Biomolecules, 2022 Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and
Han-Gang Yu +3 more
doaj +1 more source