SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway
Virology, 2022 Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most promiscuous of known inflammasomes.
Michael McIntosh +2 more
exaly +2 more sources
The 6-kilodalton peptide 1 of the family Potyviridae: small in size but powerful in function [PDF]
Frontiers in MicrobiologyThe Potyviridae family is one of the most economically significant groups of plant RNA viruses, causing severe yield losses in agriculturally important crops.
Liansheng Yu +7 more
doaj +2 more sources
Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays
Viruses, 2019 Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar +3 more
doaj +2 more sources
The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion
mBio, 2023 The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus’ cell tropism and its evasion of host innate immune responses.
Anna Luganini +6 more
doaj +2 more sources
Atomic structure of the open SARS-CoV-2 E viroporin
Science Advances, 2023 The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells.
João Medeiros‐Silva +4 more
semanticscholar +2 more sources
SARS-CoV-2 Viroporin E Induces Ca2+ Release and Neuron Cell Death in Primary Cultures of Rat Hippocampal Cells Aged In Vitro. [PDF]
Int J Mol SciThe COVID-19 pandemic was caused by infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which may lead to serious respiratory, vascular and neurological dysfunctions.
López-Vázquez S +2 more
europepmc +2 more sources
In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin
MSphere, 2020 Simian virus 40 VP4 was discovered in 2007 as a later expressed viral protein initiated from a downstream Met on the VP2/VP3 transcript. VP4’s role as a viroporin involved in viral release was supported in a series of additional articles that ...
Robert Daniels, Daniel Hebert
exaly +3 more sources
A universal cell-based method for high-throughput analysis of viroporin function and inhibition
Pharmacological ResearchViroporins are transmembrane proteins encoded mainly by RNA viruses that oligomerize to form pores essential for multiple stages of the viral life cycle.
Viktoria M.S. Kjær +3 more
doaj +2 more sources
The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin [PDF]
PLoS Pathogens, 2010 Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability.
Shinya Tanaka +26 more
core +6 more sources
NLRP3 Inflammasome Activation by Viroporins of Animal Viruses [PDF]
Viruses, 2015 Viroporins are a group of low-molecular-weight proteins containing about 50–120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly ...
Hui-Chen Guo +4 more
doaj +3 more sources