Results 31 to 40 of about 3,761 (176)

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy [PDF]

eLife, 2020
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin   +21 more
doaj   +2 more sources

The antiviral targeting potential of viroporins

Ugeskrift for laeger, 2022
Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine ...
Weis, Nina, Bentzen, Bo H, Bollerup, Signe, Rosenkilde, Mette, Glamann, Jekob B, Jensen, Louise R, Kledal, Thomas N, Sund, John D, Vinten, Caroline An, Toft-Bertelsen, Trine L   +9 more
core   +3 more sources

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein.

PLoS ONE, 2015
Viroporins are a family of low-molecular-weight hydrophobic transmembrane proteins that are encoded by various animal viruses. Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing ...
Da Ao, Hui-Chen Guo, Shi-Qi Sun, De-Hui Sun, To Sing Fung, Yan-Quan Wei, Shi-Chong Han, Xue-Ping Yao, Sui-Zhong Cao, Ding Xiang Liu, Xiang-Tao Liu   +10 more
doaj   +2 more sources

The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]

Mol Plant Pathol
The cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y, Fan X, Luan Y, Li Y, Zhao Y, Ji W, Li N, Wu X, Cheng X, Bai Y.   +9 more
europepmc   +2 more sources

Viroporins of Mpox Virus

International Journal of Molecular Sciences, 2023
Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore, characterizing new drug targets in the virus may prove advantageous to curbing the disease.
Kingshuk Basu, Miriam Krugliak, Isaiah T. Arkin   +2 more
openaire   +2 more sources

Coronavirus viroporins: structure and function [PDF]

The Ukrainian Biochemical Journal, 2021
Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction.
I. Zaloilo, Y. Rud, О. Zaloilo, L. Buchatskyi   +3 more
openaire   +2 more sources

Structural Bases for the Unconventional Activity of a Viroporin Channel. [PDF]

Biochemistry
Viroporins alter the permeability of cell membranes and regulate the initiation/progression of the viral infection cycle. However, the "unconventional" membrane channel behavior displayed by many members of the family challenges their general validation as therapeutic targets.
Wiley B, Largo E, Nabais L, Nieva JL, Domene C.   +4 more
europepmc   +3 more sources

Viroporins [PDF]

FEBS Letters, 2003
Viroporins are a group of proteins that participate in several viral functions, including the promotion of release of viral particles from cells. These proteins also affect cellular functions, including the cell vesicle system, glycoprotein trafficking and membrane permeability.
Gonzalez Portal, Maria Eugenia, Carrasco, Luis   +1 more
openaire   +3 more sources

Viroporins in the Influenza Virus [PDF]

Cells, 2019
Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C and D, with only A–C known to infect humans. Influenza A and B viruses are responsible for seasonal influenza epidemics in humans and are responsible for up to a billion flu infections ...
Janet To, Jaume Torres
openaire   +4 more sources

Viroporins: structure and biological functions [PDF]

Nature Reviews Microbiology, 2012
Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of the cell. Viroporins are crucial for viral pathogenicity owing to their involvement in several diverse
Nieva, José Luis, Madan, Vanesa, Carrasco Llamas, Luis   +2 more
openaire   +3 more sources