Results 21 to 30 of about 4,200 (198)

Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin? [PDF]

mSphere, 2020
The simian polyomavirus SV40 was reported to express Vp4, an N-terminally truncated form of the minor capsid proteins Vp2 and Vp3. Since a missense mutation of the putative Vp4 start codon (Vp2M228I) was found to give reduced progeny release and delayed ...
Stian Henriksen, Christine Hanssen Rinaldo   +1 more
doaj   +2 more sources

Membrane integration of poliovirus 2B viroporin [PDF]

Journal of Virology, 2011
Virus infections can result in a variety of cellular injuries, and these often involve the permeabilization of host membranes by viral proteins of the viroporin family.
Sánchez Martínez, Silvia, José Luis Nieva, Mingarro, Ismael, Nieva -, José Luis, Martínez-Gil, L., Luis Martínez-Gil, Bañó-Polo, Manuel, Martínez Gil, Luis, Mingarro Muñoz, Ismael, Silvia Sánchez-Martínez, Carrasco Llamas, Luis, Redondo, Natalia, Bañó Polo, Manuel, Natalia Redondo, Sánchez-Martínez, Silvia, Nieva, José Luis, Carrasco, Luis, Ismael Mingarro, Luis Carrasco, Martínez-Gil, Luis, Manuel Bañó-Polo   +20 more
core   +7 more sources

The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.

PLoS ONE, 2011
Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl, Vicky Cheng, Daniel A Donahue, Richard D Sloan, Chen Liang, John Wilkinson, Mark A Wainberg   +6 more
doaj   +2 more sources

Ebola Virus Delta Peptide Is a Viroporin [PDF]

Journal of Virology, 2017
The Ebola virus (EBOV) genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, that is produced in abundance during Ebola virus disease (EVD).
Peter C. Searson, Jing He, Lilia I. Melnik, Robert F. Garry, Taylor Fuselier, William R. Gallaher, Alexander Komin, Kalina Hristova, Cameron F. Morris, Gregory Wiedman, Charles G. Starr, William C. Wimley   +11 more
core   +3 more sources

Viroporin activity is necessary for intercellular calcium signals that contribute to viral pathogenesis. [PDF]

Sci Adv
Viruses engage in a variety of processes to subvert host defenses and create an environment amenable to replication. Here, using rotavirus as a prototype, we show that calcium conductance out of the endoplasmic reticulum by the virus encoded ion channel,
Gebert JT, Scribano FJ, Engevik KA, Huleatt EM, Eledge MR, Dorn LE, Philip AA, Kawagishi T, Greenberg HB, Patton JT, Hyser JM.   +10 more
europepmc   +2 more sources

A viroporin-like 2B protein of duck hepatitis A virus 1 that induces incomplete autophagy in DEF cells

Poultry Science, 2021
: Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that
Sai Mao, Anchun Cheng, Juan Huang
exaly   +3 more sources

Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors [PDF]

Frontiers in Microbiology, 2021
Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped single-stranded positive-sense RNA virus, is a member of the genus Betacoronavirus, family Coronaviridae.
Ulrike Breitinger, Nourhan K. M. Ali, Heinrich Sticht, Hans-Georg Breitinger   +3 more
doaj   +2 more sources

Structural Bases for the Unconventional Activity of a Viroporin Channel. [PDF]

Biochemistry
Viroporins alter the permeability of cell membranes and regulate the initiation/progression of the viral infection cycle. However, the “unconventional” membrane channel behavior displayed by many members of the family challenges their general validation ...
Wiley B, Largo E, Nabais L, Nieva JL, Domene C.   +4 more
europepmc   +2 more sources

Targeting the US21 viroporin of human cytomegalovirus by calcium channel blockers as a new antiviral strategy. [PDF]

Curr Res Microb Sci
Highlights • CCBs bind the inner pore of the HCMV US21 viroporin and abolish pUS21-mediated ER Ca2+ leakage.• CCBs inhibit HCMV replication.• CCBs prevent the cytobiological consequences of pUS21 expression.• CCBs treatment restores ER Ca2+ levels to ...
Sibille G, Loggia D, Catucci G, Gilardino A, Pla AF, Nardo GD, Munaron L, Gilardi G, Gribaudo G, Luganini A.   +9 more
europepmc   +2 more sources

Recovirus NS1-2 Has Viroporin Activity That Induces Aberrant Cellular Calcium Signaling To Facilitate Virus Replication

MSphere, 2019
Enteric viruses in the Caliciviridae family cause acute gastroenteritis in humans and animals, but the cellular processes needed for virus replication and disease remain unknown.
Joseph M Hyser, Jacob Perry, Alexandra Chang-Graham   +2 more
exaly   +3 more sources