Results 21 to 30 of about 3,761 (176)
The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.
PLoS ONE, 2011 Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl +6 more
doaj +2 more sources
Membrane integration of poliovirus 2B viroporin [PDF]
Journal of Virology, 2011 Virus infections can result in a variety of cellular injuries, and these often involve the permeabilization of host membranes by viral proteins of the viroporin family.
Sánchez Martínez, Silvia +20 more
core +7 more sources
In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin.
MSphere, 2020 Simian virus 40 VP4 was discovered in 2007 as a later expressed viral protein initiated from a downstream Met on the VP2/VP3 transcript. VP4’s role as a viroporin involved in viral release was supported in a series of additional articles that ...
Robert Daniels, Daniel N Hebert
exaly +3 more sources
A WEEV 6K viroporin activates MLKL-dependent necroptosis to drive inflammatory injury [PDF]
Cell Death DiscoveryNeurotropic alphavirus infection is characterized by neuronal injury and sustained neuroinflammation, yet the viral determinants linking membrane perturbation to host inflammatory damage remain poorly defined.
Ziyan Zhou +3 more
doaj +2 more sources
MSphere, 2019 Enteric viruses in the Caliciviridae family cause acute gastroenteritis in humans and animals, but the cellular processes needed for virus replication and disease remain unknown.
Joseph M Hyser +2 more
exaly +3 more sources
Viroporin-mediated Membrane Permeabilization [PDF]
Journal of Biological Chemistry, 2002 Enterovirus nonstructural 2B protein is involved in cell membrane permeabilization during late viral infection. Here we analyze the pore forming activity of poliovirus 2B and several of its variants.
Agirre, Aitziber +7 more
core +2 more sources
The 6-kilodalton peptide 1 of the family Potyviridae: small in size but powerful in function [PDF]
Frontiers in MicrobiologyThe Potyviridae family is one of the most economically significant groups of plant RNA viruses, causing severe yield losses in agriculturally important crops.
Liansheng Yu +7 more
doaj +2 more sources
Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays
Viruses, 2019 Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar +3 more
doaj +2 more sources
The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin [PDF]
PLoS Pathogens, 2010 Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability.
Shinya Tanaka +26 more
core +6 more sources
NLRP3 Inflammasome Activation by Viroporins of Animal Viruses [PDF]
Viruses, 2015 Viroporins are a group of low-molecular-weight proteins containing about 50–120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly ...
Hui-Chen Guo +4 more
doaj +3 more sources