Results 21 to 30 of about 4,749 (194)
SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling [PDF]
Communications BiologyORF3a, the most abundantly expressed accessory protein of SARS-CoV-2, plays an essential role in virus egress by inactivating lysosomes through their deacidification. However, the mechanism underlying this process remains unclear.
Antonio Michelucci +9 more
doaj +2 more sources
Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection [PDF]
eLifeFlaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes ...
Emma Brown +16 more
doaj +2 more sources
Viroporins: A new target for fighting viral infections [PDF]
, 2017 Over the last years an increasing number of viruses have jumped into the mass media and several names or acronyms (Ebola, zika, SARS, MERS,…) have become familiar to the general public because of the high mortality rates associated with their infection ...
Aguilella, Vicente
core +2 more sources
The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]
Mol Plant PatholThe cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y +9 more
europepmc +2 more sources
Computational investigation in inhibitory effects of amantadine on classical swine fever virus p7 ion channel activity [PDF]
Scientific ReportsClassical swine fever virus (CSFV) p7 viroporin plays crucial roles in cellular ion balance and permeabilization. The antiviral drug amantadine effectively inhibits viral replication by blocking the activity of CSFV p7 viroporin.
Xiaowei Chen, Xiao Wang
doaj +2 more sources
Coronavirus viroporins: structure and function [PDF]
The Ukrainian Biochemical Journal, 2021 Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction.
I. Zaloilo +3 more
openaire +2 more sources
Impact of vesicular stomatitis virus M proteins on different cellular functions [PDF]
, 2015 This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Carrasco Llamas, Luis +3 more
core +16 more sources
International Journal of Molecular Sciences, 2023 Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore, characterizing new drug targets in the virus may prove advantageous to curbing the disease.
Kingshuk Basu +2 more
openaire +2 more sources
FEBS Letters, 2003 Viroporins are a group of proteins that participate in several viral functions, including the promotion of release of viral particles from cells. These proteins also affect cellular functions, including the cell vesicle system, glycoprotein trafficking and membrane permeability.
Gonzalez Portal, Maria Eugenia +1 more
openaire +3 more sources
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis [PDF]
, 2014 Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function in virus-host interaction.
Aguilella, Vicente +10 more
core +12 more sources