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ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress [PDF]
Developmental Cell, 2021 Viral entry and egress are important determinants of virus infectivity and pathogenicity. β-coronaviruses, including the COVID-19 virus SARS-CoV-2 and mouse hepatitis virus (MHV), exploit the lysosomal exocytosis pathway for egress. Here, we show that SARS-CoV-2 ORF3a, but not SARS-CoV ORF3a, promotes lysosomal exocytosis.
Di Chen, Sun Long, Mingming Ji
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SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway
Virology, 2022 Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most promiscuous of known inflammasomes. Ectopically expressed ORF3a triggers IL-1β expression via NFκB, thus priming the inflammasome.
Huanzhou Xu +2 more
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Molecular conservation and differential mutation on ORF3a gene in Indian SARS-CoV2 genomes
Genomics, 2020 AbstractA global emergency due to the COVID-19 pandemic demands various studies related to genes and genomes of the SARS-CoV2. Among other important proteins, the role of accessory proteins are of immense importance in replication, regulation of infections of the coronavirus in the hosts.
Sk Sarif Hassan +2 more
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SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction
Virus Research, 2023 Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-2 infection. Patients with severe COVID-19 exhibit robust induction of proinflammatory cytokines, which are closely associated with the development of acute respiratory distress syndrome.
Jiahong Wu
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Investigating SARS-CoV-2 ORF3a binding to human TRAF2 and TRAF3
The Journal of Immunology, 2023Abstract Severe COVID-19, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is characterized by widespread inflammation and cytokine storm. A number of viral proteins are capable of inducing inflammatory responses, one of which is open reading frame 3a (ORF3a). ORF3a from SARS-CoV shares 73% homology with SARS-CoV-2
Brianna M Busscher +4 more
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Regulation of autophagy by SARS‐CoV‐2: The multifunctional contributions of ORF3a
Journal of Medical Virology, 2023AbstractSevere acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) regulates autophagic flux by blocking the fusion of autophagosomes with lysosomes, causing the accumulation of membranous vesicles for replication. Multiple SARS‐CoV‐2 proteins regulate autophagy with significant roles attributed to ORF3a. Mechanistically, open reading frame 3a (ORF3a)
Mohd Shariq +4 more
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Μελέτη της πρωτεΐνης ORF3a του SARS-CoV-2
2022Ο SARS-CoV-2, είναι ένας ιός θετικού μονόκλωνου RNA, με μέγεθος γονιδιώματος περίπου 30.000 βάσεις και ο οποίος κωδικοποιεί τριών ειδών πρωτεΐνες (δομικές, μη δοκιμές και βοηθητικές). Η πρωτεΐνη ORF3a, η οποία είναι η μεγαλύτερη από τις βοηθητικές πρωτεΐνες του SARS-CoV-2, αποτελείται από 274 αμινοξέα (~33 kDa) και συμβάλλει τόσο στον σχηματισμό νέων ...
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Analysis of SARS-CoV-2 ORF3a structure reveals chloride binding sites
2020AbstractSARS-CoV-2 ORF3a is believed to form ion channels, which may be involved in the modulation of virus release, and has been implicated in various cellular processes like the up-regulation of fibrinogen expression in lung epithelial cells, downregulation of type 1 interferon receptor, caspase-dependent apoptosis, and increasing IFNAR1 ...
Valeria, Marquez-Miranda +6 more
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Genetic variety of ORF3a shapes SARS‐CoV‐2 fitness through modulation of lipid droplet
Journal of Medical Virology, 2023AbstractSevere acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection leads to the accumulation of lipid droplets (LD), the central hubs of the lipid metabolism, in vitro or in type II pneumocytes and monocytes from coronavirus disease 19 (COVID‐19) patients and blockage of LD formation by specific inhibitors impedes SARS‐CoV‐2 replication ...
Weili Wang +7 more
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Impact of ORF3a-Q57H variant of SARS-CoV-2 on apoptotic signaling cascades
Physiology, 2023Introduction: Direct infection and viral protein expression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the respiratory system, and other organs including the heart, contribute to multi-organ dysfunction during COVID-19. We previously showed that the protein encoded by the open reading frame 3a (ORF3a) gene of SARS-CoV-2, which ...
Maria Landherr +5 more
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