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Novel Multi-Antigen Orf-Virus-Derived Vaccine Elicits Protective Anti-SARS-CoV-2 Response in Monovalent and Bivalent Formats. [PDF]
Vaccines (Basel)Burri DJ +6 more
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Pharmacokinetic and Environmental Risk Assessment of Prime-2-CoV, a Non-Replicating Orf Virus-Based Vaccine against SARS-CoV-2. [PDF]
Vaccines (Basel)Metz C, Haug V, Müller M, Amann R.
europepmc +1 more source
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Reviews in Medical Virology, 2017
SummaryOrf virus (ORFV) is an important pathogen responsible for a highly contagious zoonotic viral infection that threatens those who handle sheep and goats. Orf virus is the prototype of the Parapoxvirus genus, and its resilience in the environment and ability to reinfect its host has contributed to the spread and maintenance of the infection in many
Christina Bergqvist +2 more
exaly +3 more sources
SummaryOrf virus (ORFV) is an important pathogen responsible for a highly contagious zoonotic viral infection that threatens those who handle sheep and goats. Orf virus is the prototype of the Parapoxvirus genus, and its resilience in the environment and ability to reinfect its host has contributed to the spread and maintenance of the infection in many
Christina Bergqvist +2 more
exaly +3 more sources
The immune and inflammatory response to orf virus
Comparative Immunology, Microbiology and Infectious Diseases, 1997Orf virus is a zoonotic, epitheliotropic DNA parapox virus that principally infects sheep and goats. The fact that the virus can repeatedly reinfect sheep has provoked an interest in the underlying cellular, virological and molecular mechanisms for its apparent escape from the host protective immune response.
D M Haig, Colin J Mcinnes, D Deane
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An Overwiev of ORF Virus Infection in Humans and Animals
Recent Patents on Anti-infective Drug Discovery, 2017Orf virus is a DNA virus that belongs to the Parapoxvirus genus. The virus is a causative agent of orf in humans or contagious ecthyma in animals which is mostly seen in sheep, goat and cattle.Orf is an emerging zoonosis with an increasing number of worldwide outbreaks that have been reported.
Hayati Demiraslan +2 more
exaly +4 more sources
Immunomodulation by virulence proteins of the parapoxvirus orf virus
Veterinary Immunology and Immunopathology, 1999Three orf virus putative virulence proteins are described that exhibit immunomodulatory functions. The OVIFNR gene at the left terminus of the viral genome encodes an interferon resistance protein with homology to the E3L gene of vaccinia virus. OVIFNR functions by preventing a dsRNA-dependent kinase from inhibiting virus and cell protein synthesis as ...
D M Haig
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Virology, 1964
Abstract Three methods can be used to show that both upper and lower surfaces of orf virus particles are seen in sodium phosphotungstate-stained electron micrographs. These have demonstrated that the characteristic tubular thread structure of the wall of the particle is in the form of a left-hand spiral coil of a single thread.
J, NAGINGTON, A A, NEWTON, R W, HORNE
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Abstract Three methods can be used to show that both upper and lower surfaces of orf virus particles are seen in sodium phosphotungstate-stained electron micrographs. These have demonstrated that the characteristic tubular thread structure of the wall of the particle is in the form of a left-hand spiral coil of a single thread.
J, NAGINGTON, A A, NEWTON, R W, HORNE
openaire +2 more sources
Ocular Infection with Orf Virus
American Journal of Ophthalmology, 1984Orf virus infection of the pericanthal eyelid skin and conjunctiva was diagnosed by electron microscopy. Orf is a paravaccinia virus responsible for contagious pustular dermatitis in sheep and goats. It occasionally affects humans. The patient was a farmwife who had recently handled lambs.
G, Freeman, A J, Bron, B, Juel-Jensen
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2020
Capripox infections of small ruminants, namely goatpox and sheeppox, are OIE notifiable and transboundary animal diseases. Goatpox and sheeppox are prevalent in some parts of Africa, the Middle East, and Asia with occasional outbreaks in regions of Europe.
Gnanavel Venkatesan +4 more
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Capripox infections of small ruminants, namely goatpox and sheeppox, are OIE notifiable and transboundary animal diseases. Goatpox and sheeppox are prevalent in some parts of Africa, the Middle East, and Asia with occasional outbreaks in regions of Europe.
Gnanavel Venkatesan +4 more
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Conservation and variation in orf virus genomes
Virology, 1987The genomes of several orf virus strains were analyzed with the restriction endonucleases EcoRI, HindIII, BamHI, and KpnI, and cleavage site maps were deduced. In general, the right half of the genome showed conservation of restriction sites compared with the left half.
A J, Robinson +4 more
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