Results 71 to 80 of about 126,031 (209)

Activation of CXCL-8 Transcription by Hepatitis E Virus ORF-1 via AP-1

Mediators of Inflammation, 2015
Hepatitis E virus (HEV) is a small nonenveloped single-stranded positive-sense RNA virus and is one of the major causes for acute hepatitis worldwide. CXCL-8 is a small multifunctional proinflammatory chemokine.
Zhubing Li, Lu Chen, Qiang Liu
doaj   +1 more source

In vitro inhibition of transmissible gastroenteritis coronavirus replication in swine testicular cells by short hairpin RNAs targeting the ORF 7 gene

Virology Journal, 2012
Background Transmissible gastroenteritis (TGE) is a highly contagious viral disease of swine, characterized by severe vomiting, diarrhea, and high mortality.
He Lei, Zhang Yan-ming, Dong Ling-juan, Cheng Min, Wang Jing, Tang Qing-hai, Wang Gang   +6 more
doaj   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Heterologous expression of HCoV-HKU1 ORF 7b by mouse hepatitis virus protects against severe disease during murine infection.

PLoS Pathogens
Coronaviruses express a repertoire of accessory proteins for evading host immune responses. A small internal (I) accessory gene overlaps with the nucleocapsid (N) gene in an alternative reading frame of viruses that belong to the genus Betacoronavirus ...
Chaminda D Gunawardene, Isha Pandey, Shruti Chatterjee, Yoatzin Peñaflor-Téllez, Abby Odle, Abbey N Warren, Adriana Messyasz, Ricardo Rajsbaum, Alan Sariol, Lok-Yin Roy Wong   +9 more
doaj   +1 more source

Disease of South American camelids in England and Wales: Analysis of diagnoses from Animal and Plant Health Agency laboratory submissions between 2012 and 2021

Veterinary Record, EarlyView.
Abstract Background South American camelids (SACs) have become increasingly popular in the UK. Consequently, knowledge among veterinary practitioners about diseases in these non‐native species has improved, although gaps remain. The remit of this study was to identify common diseases of SACs based on Animal and Plant Health Agency (APHA) surveillance ...
Sonja Jeckel, Carissa Xian Chow, David Jorge   +2 more
wiley   +1 more source

LsFAMeT and LsJHAMT coordinate JH biosynthesis to regulate fecundity in Laodelphax striatellus

Insect Science, EarlyView.
The small brown planthopper (SBPH), Laodelphax striatellus, can trigger large‐scale outbreaks when encountering suitable habitats during migration due to their strong reproductive ability. This study investigated the role of juvenile hormone (JH) in regulating SBPH reproduction.
Yan Guo, Bing‐Bing Shi, Xue‐Qi Zhang, Qiong Yang   +3 more
wiley   +1 more source

Gut Microbiota Analysis and Comparison in Forest Musk Deer (Moschus berezovskii) of Different Ages and Musk‐Secreting Periods

Integrative Zoology, EarlyView.
Metagenomic sequencing was used to analyze fecal microbiota of captive male forest musk deer (FMD) from the Sichuan Institute of Musk Deer Breeding across ages and musk‐secreting periods. Gut microbiota was generally stable and dominated by Firmicutes, while age and musk secretion shaped microbial composition and function, with musk collection linked ...
Jiuyan Jiang, Qiuping Huang, Fei Wu, Pingwei Liang, Linping Fan, Xia Zhou, Chengli Zheng, Xin Shi, Huina Song, Ji Wang, Jing Xue Luo, Ji Chen, Qinlin Yang, Siqi Peng, Lingqian Yin, Dejun Zeng, Hang Jie, Guangxiang Zhu   +17 more
wiley   +1 more source

Transcript mapping of the ‘early’ genes of Orf virus

Journal of General Virology, 2003
The full complement of genes encoded by Orf virus (ORFV) is not yet known. A cDNA library was constructed using mRNA isolated 5 h post-infection from cells infected with ORFV in vitro and grown in the presence of cytosine arabinoside. Using 12 non-overlapping probes representing the entire genome of the Orf-11 strain of the virus, cDNA clones ...
Ann R, Wood, Colin J, McInnes
openaire   +2 more sources

Exploring First Interactions Between Ostreid Herpesvirus 1 (OsHV-1) and Its Host, Crassostrea gigas: Effects of Specific Antiviral Antibodies and Dextran Sulfate

Frontiers in Microbiology, 2019
Viral entry mechanisms of herpesviruses constitute a highly complex process which implicates several viral glycoproteins and different receptors on the host cell surfaces. This initial infection stage was currently undescribed for Ostreid herpes virus 1 (
Claire Martenot, Nicole Faury, Benjamin Morga, Lionel Degremont, Jean-Baptiste Lamy, Maryline Houssin, Tristan Renault   +6 more
doaj   +1 more source

Inhibin βB Mediates Oligotrophic Adaptation via Regulating Muscle Satellite Cell Proliferation and Differentiation in Schizopygopsis younghusbandi

Integrative Zoology, EarlyView.
① Nutrient deficiency upregulates inhibin βB, activating SMAD signaling to promote p21. Increased p21 inhibits mcm2/mcm4/mcm5 and cyclin E2, inducing G1‐phase arrest, slowing growth, and reducing energy consumption. ② Inhibin βB also upregulates pdgf‐c, which induces α‐SMA, leading to muscle satellite cell fibrosis.
Weiqiang Li, He Gao, Chaowei Zhou, Luo Lei, Junting Li, Chao Ma, Zitu Ma, Mengwei Yao, Kexin Ma, Yunpeng Xiang, Yan Zhou, Yongrui Lu, Da Ji, Minghong Wei, Luohao Xu, Zhaofang Han, Haiping Liu   +16 more
wiley   +1 more source