Results 1 to 10 of about 56,595 (259)
Organ-on-a-Chip and Lab-on-a-Chip Technologies in Cardiac Tissue Engineering [PDF]
BiomimeticsMicrofluidic technologies have ushered in a new era in cardiac tissue engineering, providing more predictive in vitro models compared to two-dimensional culture studies. This review examines Organ-on-a-Chip (OoC) and Lab-on-a-Chip (LoC) platforms, with a
Daniele Marazzi +3 more
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Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
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Organ-on-a-chip and the kidney
Kidney Research and Clinical Practice, 2015 Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated.
Sejoong Kim, Shuichi Takayama
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Organ-on-a-chip: future of female reproductive pathophysiological models [PDF]
Journal of NanobiotechnologyThe female reproductive system comprises the internal and external genitalia, which communicate through intricate endocrine pathways. Besides secreting hormones that maintain the female secondary sexual characteristics, it also produces follicles and ...
Zhi-Min Deng +6 more
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Organ-on-a-Chip Applications in Microfluidic Platforms. [PDF]
Micromachines (Basel)Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication processes of microfluidic devices.
An L, Liu Y, Liu Y.
europepmc +4 more sources
Micromachines, 2021 The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices.
Yoel Goldstein +7 more
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Bioengineering, 2023 This paper presents an innovative experimental setup that employs the principles of audio technology to subject adherent cells to rhythmic vertical vibrations.
Dongho Kwak +3 more
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Micromachines, 2021 Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun +4 more
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A directional 3D neurite outgrowth model for studying motor axon biology and disease
Scientific Reports, 2021 We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel,
Xandor M. Spijkers +5 more
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Open Research Europe, 2023 It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational ...
Giulia Malaguarnera +2 more
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