Results 21 to 30 of about 61,131 (327)
Engineering Organ-on-a-Chip Systems for Vascular Diseases.
Arteriosclerosis, Thrombosis and Vascular Biology, 2023 Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity and mortality worldwide. Traditional in vitro models for studying vascular diseases have limitations, as they do not fully recapitulate the complexity of the in vivo
A. Shakeri +6 more
semanticscholar +1 more source
Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Biosensors, 2023 The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs.
Dimple Palanilkunnathil Thomas +3 more
doaj +1 more source
Journal of Extracellular Vesicles, 2022 Mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs) show therapeutic potential in multiple disease models, including kidney injury.
Vivian V T Nguyen +13 more
semanticscholar +1 more source
Multi-scale cellular engineering: From molecules to organ-on-a-chip. [PDF]
, 2020 Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems.
Cahan, Patrick +8 more
core +2 more sources
Cystic Fibrosis Human Organs-on-a-Chip [PDF]
Micromachines, 2021 Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most epithelial cells.
Herbert Luke Ogden +4 more
openaire +3 more sources
Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
core +1 more source
Toxicology Research and Application, 2017 In the last few years, considerable attention has been given to in vitro models in an attempt to reduce the use of animals and to decrease the rate of preclinical failure associated with the development of new drugs. Simple two-dimensional cultures grown in a dish are now frequently replaced by organotypic cultures with three-dimensional (3-D ...
David Bovard +4 more
openaire +1 more source
Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review
Cancers, 2022 Simple Summary Cancer is one of the diseases with a high mortality rate worldwide. Of the current strategies to study new diagnostic and treating tools, organs-on-chip are quite promising regarding the achievement of more personalized medicine.
I. Gonçalves +9 more
semanticscholar +1 more source
3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review
Italian National Conference on Sensors, 2021 Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell ...
V. Carvalho +9 more
semanticscholar +1 more source
Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
Frontiers in Bioengineering and Biotechnology, 2023 Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is
Cristian F. Rodríguez +6 more
doaj +1 more source