Results 61 to 70 of about 61,131 (327)

Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer

Micromachines, 2021
Current in vitro models have significant limitations for new respiratory disease research and rapid drug repurposing. Lung on a chip (LOAC) technology offers a potential solution to these problems.
Roberts Rimsa, Artis Galvanovskis, Janis Plume, Felikss Rumnieks, Karlis Grindulis, Gunita Paidere, Sintija Erentraute, Gatis Mozolevskis, Arturs Abols   +8 more
doaj   +1 more source

TapeTech microfluidic connectors: adhesive tape-enabled solution for organ-on-a-chip system integration

Lab on a Chip
A longstanding challenge in microfluidics has been the efficient delivery of fluids from macro-scale pumping systems into microfluidic devices, known as the “world-to-chip” problem.
Terry Ching, A. C. van Steen, Delaney Gray-Scherr, J. L. Teo, A. Vasan, Joshua Jeon, J. Shah, Aayush Patel, Amy E. Stoddard, Jennifer Bays, J. Eyckmans, Christopher S. Chen   +11 more
semanticscholar   +1 more source

Microfluidics for Advanced Drug Delivery Systems. [PDF]

, 2015
Considerable efforts have been devoted towards developing effective drug delivery methods. Microfluidic systems, with their capability for precise handling and transport of small liquid quantities, have emerged as a promising platform for designing ...
Dokmeci, Mehmet R, Ghaemmaghami, Amir, Khademshosseini, Ali, Riahi, Reza, Shaegh, Seyed Ali Mousavi, Tamayol, Ali   +5 more
core   +1 more source

High-resolution low-cost LCD 3D printing for microfluidics and organ-on-a-chip devices.

Lab on a Chip
The fabrication of microfluidic devices has progressed from cleanroom manufacturing to replica molding in polymers, and more recently to direct manufacturing by subtractive (e.g., laser machining) and additive (e.g., 3D printing) techniques, notably ...
Houda Shafique, V. Karamzadeh, Geunyong Kim, Molly L. Shen, Yonatan Morocz, A. Sohrabi-Kashani, David Juncker   +6 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Organ-on-a-chip: current gaps and future directions. [PDF]

, 2022
As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that is attracting interest from both basic and translational scientists.
Amour, Augustin, Balkwill, Frances, Beken, Sonja, Candarlioglu, Pelin L, Dal Negro, Gianni, David, Rhiannon, Guenat, Olivier, Harris, Kate, Hughes, David, Morgan, Hywel, Rowan, Wendy, Screen, Hazel   +11 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

PLGA Nanofiber/PDMS Microporous Composite Membrane-Sandwiched Microchip for Drug Testing

Micromachines, 2020
Lung-on-a-chip devices could provide new strategies for a biomimetic lung cell microenvironment and construction of lung disease models in vitro, and are expected to greatly promote the development of drug evaluation, toxicological detection, and disease
Wei Li, Xindi Sun, Bing Ji, Xingyuan Yang, Bingpu Zhou, Zhanjun Lu, Xinghua Gao   +6 more
doaj   +1 more source

Alveolus Lung-on-a-Chip Platform: A Proposal

Chemosensors, 2021
Respiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments ...
Noelia Campillo, Vinicius Rosa Oliveira, Renata Kelly da Palma   +2 more
doaj   +1 more source

Organ-on-a-chip model of vascularized human bone marrow niches

bioRxiv, 2020
Animal models of bone marrow have limited spatial and temporal resolution to observe biological events (intravasation and cellular egress) and are inadequate to dissect dynamic events at the niche level (100 microns). Utilizing microfluidic and stem cell
D. Glaser, Matthew B. Curtis, Peter A. Sariano, Zachary A. Rollins, B. Shergill, Aravind Anand, Alyssa M. Deely, Venktesh S. Shirure, L. Anderson, Jeremy M. Lowen, Natalie R Ng, K. Weilbaecher, D. Link, Steven C. George   +13 more
semanticscholar   +1 more source