Results 231 to 240 of about 59,126 (260)
Some of the next articles are maybe not open access.
2016
The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
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The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
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Cell Host and Microbe, 2021
The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The difficulty of inferring causation from metagenomic microbiome sequencing studies and from mouse-human interspecies differences has prompted the development of sophisticated in vitro models of human gut-microbe interactions. Here, we review
Puschhof, Jens +2 more
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The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The difficulty of inferring causation from metagenomic microbiome sequencing studies and from mouse-human interspecies differences has prompted the development of sophisticated in vitro models of human gut-microbe interactions. Here, we review
Puschhof, Jens +2 more
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Organs-on-chips: research and commercial perspectives
Drug Discovery Today, 2017Traditional preclinical drug testing methods utilize animal models to predict pharmacology and toxicology profiles. However, the data obtained from such methods cannot be directly extrapolated to humans and often do not provide a safe starting dose for first-in-human studies.
Aarathi, Balijepalli +1 more
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Bioinspired Engineering of Organ-on-Chip Devices
2019The human body can be viewed as an organism consisting of a variety of cellular and non-cellular materials interacting in a highly ordered manner. Its complex and hierarchical nature inspires the multi-level recapitulation of the human body in order to gain insights into the inner workings of life.
Li, Wang +3 more
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Developing organs-on-chips for biomedicine
Science Bulletin, 2022Yujuan, Zhu +3 more
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Adoption of organ-on-chip platforms by the pharmaceutical industry
Nature Reviews Drug Discovery, 2021Paul Vulto, Jos Joore, Joore Jos
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Clamping strategies for organ-on-a-chip devices
Nature Reviews Materials, 2023Lorenzo Moroni +2 more
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Organ-on-a-Chip: A New Paradigm for Drug Development
Trends in Pharmacological Sciences, 2021Chao Ma, Yansong Peng, Hongtong Li
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Organ-on-a-chip: A new tool for in vitro research
Biosensors and Bioelectronics, 2022Jiuchuan Guo, Jinhong Guo
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