Results 211 to 220 of about 69,325 (340)

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Human Organoids and Organ-on-Chip for Biotoxin Assessment: Applications, Best Practices, and a Translational Roadmap. [PDF]

Toxins (Basel)
Li M, Huang S, Jia J, Feng Y, Zhang J.
europepmc   +1 more source

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish” [PDF]

, 2016

core   +1 more source

Design strategy primer for organ-on-chips.

Biomaterials translational
Organ-on-a-chip (OoC) has emerged as a revolutionary technique in recent decades, capable of replicating essential aspects of physiological and pathophysiological processes of human organs in vitro. Serving as an effective tissue culture method for creating digital twins, OoCs show significant promise and have found applications in disease modelling ...
Cao, Ting, Xu, Peicheng, Yang, Chen, Chen, Yu, Wang, Yongcheng, Zhang, Jiayu, Ye, Fangfu   +6 more
openaire   +2 more sources

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, EarlyView.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

A Patient-Derived Organ-on-Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer. [PDF]

Adv Sci (Weinh)
Adnan D, de Barros NR, Santovito LS, Cheng X, Lawrence KM, Barnett MK, Boetto MD, Mehta N, Singh A, Cheng L, Huang X, Bishehsari F.   +11 more
europepmc   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

The ethical aspects of human organ-on-chip models: A mapping review. [PDF]

Stem Cell Reports
Weidema J, de Vries M, Mummery C, de Graeff N.   +3 more
europepmc   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Advancing Organ-on-Chip Models With a Sacrificial Granular Hydrogel Strategy for Enhanced Permeability and Biomimicry. [PDF]

Small Methods
Caires HR, Castillo-Fernández Ó, Sima N, Magalhães MV, Benavent-Claró A, Masó-Castro N, Roobsoong W, Fernandez-Becerra C, Hernández-Machado A, Del Portillo HA, Barrias CC.   +10 more
europepmc   +1 more source