Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc [PDF]
JOR Spine, 2022 Intervertebral disc degeneration is a common cause of low back pain, the leading cause of disability worldwide. Appropriate preclinical models for intervertebral disc research are essential to achieving a better understanding of underlying ...
Shirley N. Tang +13 more
doaj +2 more sources
Intestine Explants in Organ Culture: A Tool to Broaden the Regenerative Studies in Echinoderms [PDF]
Journal of Marine Science and Engineering, 2022 The cellular events underlying intestine regrowth in the sea cucumber Holothuria glaberrima have been described by our group. Currently, the molecular and signaling mechanisms involved in this process are being explored.
Samir A. Bello +1 more
doaj +2 more sources
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc [PDF]
JOR SpineBackground Disc degeneration is associated with repetitive violent injuries. This study aims to explore the impact of repetitive strikes loading on the biology and biomechanics of intervertebral discs (IVDs) using an organ culture model.
Jiaxiang Zhou +12 more
doaj +2 more sources
Stem Cell Growth and Differentiation in Organ Culture: New Insights for Uterine Fibroid Treatment [PDF]
Biomedicines, 2022 Organ culture allows for the understanding of normal and tumor cell biology, and tissues generally remain viable for 5–7 days. Strikingly, we determined that myometrial and MED12 mutant leiomyoma cells repopulated cell-depleted tissue slices after 20 ...
Ana Salas +6 more
doaj +2 more sources
Regeneration of amputated mice digit tips by including Wnt signaling pathway with CHIR99021 and IWP-2 chemicals in limb organ culture system [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Mammals have limited limb regeneration compared to amphibians. The role of Wnt signaling pathways in limb regeneration has rarely been studied.
Leila Taghiyar +3 more
doaj +2 more sources
A review on the evolution of methods for intestinal in vitro organ culture and its application in veterinary science. [PDF]
Vet World, 2023 Cortez BRS, Guedes RMC.
europepmc +3 more sources
Correction to: Protective effect of the extremolytes ectoine and hydroxyectoine in a porcine organ culture. [PDF]
Graefes Arch Clin Exp Ophthalmol, 2021 Tsai T +5 more
europepmc +3 more sources
The influence of intervertebral disc overloading on nociceptor calcium flickering
JOR Spine, 2023 Introduction Mechanical overloading can trigger a degenerative‐like cascade in an organ culture of intervertebral disc (IVD). Whether the overloaded IVD can influence the activation of nociceptors (i.e., the damage sensing neurons) remains unknown.
Jan Gewiess +6 more
doaj +1 more source
In vitro spermatogenesis: In search of fully defined conditions
Frontiers in Cell and Developmental Biology, 2023 A complete reconstruction of spermatogenesis in vitro under fully defined conditions still has not been achieved. However, many techniques have been proposed to get closer to that aim. Here we review the current progress in the field.
A. Yu. Kulibin, E. A. Malolina
doaj +1 more source
JOR Spine, 2021 Introduction The goal of this study is to characterize transcriptome changes and gene regulation networks in an organ culture system that mimics early post‐traumatic intervertebral disc (IVD) degeneration.
Shangbin Cui +7 more
doaj +1 more source