Results 51 to 60 of about 1,028,257 (352)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organic Anion and Cation Transporter Expression and Function During Embryonic Kidney Development and in Organ Culture Model Systems [PDF]

, 2006
Background Organic anion and cation transporters (OATs, OCTs and OCTNs) mediate the proximal tubular secretion of numerous clinically important compounds, including various commonly prescribed pharmaceuticals.
Bush, Kevin T., Eraly, Satish A., Nigam, Sanjay K., Sweet, Douglas H.   +3 more
core   +2 more sources

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine

eLife, 2022
In recent years, live-imaging techniques have been developed for the adult midgut of Drosophila melanogaster that allow temporal characterization of key processes involved in stem cell and tissue homeostasis.
Marco Marchetti, Chenge Zhang, Bruce A Edgar   +2 more
doaj   +1 more source

Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries [PDF]

, 2010
Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase ...
Ansar, S., Edvinsson, L., Sandhu, Hardip
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice. [PDF]

, 2015
UnlabelledPeritoneal disseminated cancer is highly treatment resistant. We here report the efficacy of intraperitoneal (i.p.) administration of tumor-targeting Salmonella typhimurium A1-R in a nude mouse model of disseminated human ovarian cancer.
Bouvet, Michael, Hiroshima, Yukihiko, Hoffman, Robert M, Matsubara, Hisahiro, Matsumoto, Yasunori, Miwa, Shinji, Toneri, Makoto, Tsuchiya, Hiroyuki, Uehara, Fuminari, Yamamoto, Mako, Yano, Shuya, Zhang, Yong, Zhao, Ming   +12 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Effect of Exogenous Plant Growth Regulators on Antioxidant Defense in Zucchini Cotyledons Under Different Light Regimes

Agriculture
Epigeal cotyledons with excised embryonic axes are often used as a model system to study the processes of cell division and expansion. These processes are regulated by diverse phytohormones and signaling molecules.
Asya Petrova, Zornitsa Katerova, Iskren Sergiev, Dessislava Todorova   +3 more
doaj   +1 more source

Evaluation of the effects of titanium dioxide nanoparticles on cultured Rana catesbeiana tailfin tissue

Frontiers in Genetics, 2013
Nanoparticles (NPs), materials that have one dimension less than 100 nm, are used in manufacturing, health and food products, and consumer products including cosmetics, clothing and household appliances.
S. Austin eHammond, Amanda eCarew, Caren eHelbing   +2 more
doaj   +1 more source