Results 51 to 60 of about 1,034,083 (358)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Glucose concentration modulates bovine intervertebral disc response under physiological loading

Frontiers in Bioengineering and Biotechnology
IntroductionEx vivo organ culture is a widely accepted model in intervertebral disc (IVD) research, providing valuable insights into pathology and potential new treatments.
D. Zuncheddu, D. Zuncheddu, M. Muerner, M. Muerner, K. Klavins, K. Klavins, M. J. Stoddart, L. B. Creemers, S. Grad, S. Grad   +9 more
doaj   +1 more source

In extremis diagnosis of celiac disease and concomitant wheat allergy

The Turkish Journal of Gastroenterology, 2018
Celiac disease (CD) and concomitant wheat allergy are not commonly described in the literature. Both can have almost the same treatment consisting of a gluten-free or wheat-free diet.
Raffaele Borghini, Giuseppe Donato, Mariacatia Marino, Rossela Casale, Marco Di Tola, Antonio Picarelli   +5 more
doaj   +1 more source

Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model

Frontiers in Bioengineering and Biotechnology, 2020
Discogenic low back pain (LBP) is a main cause of disability and inflammation is presumed to be a major driver of symptomatic intervertebral disc degeneration (IDD).
Zhen Li, Yannik Gehlen, Yannik Gehlen, Fabian Heizmann, Fabian Heizmann, Sibylle Grad, Mauro Alini, R. Geoff Richards, R. Geoff Richards, David Kubosch, Norbert Südkamp, Kaywan Izadpanah, Eva Johanna Kubosch, Gernot Lang   +13 more
doaj   +1 more source

Intervertebral Disc Degeneration Models for Pathophysiology and Regenerative Therapy -Benefits and Limitations

Journal of Investigative Surgery, 2022
Aim: This review summarized the recent intervertebral disc degeneration (IDD) models and described their advantages and potential disadvantages, aiming to provide an overview for the current condition of IDD model establishment and new ideas for new ...
Yidian Wang, Jihe Kang, Xudong Guo, Daxue Zhu, Mingqiang Liu, Liang Yang, Guangzhi Zhang, Xuewen Kang   +7 more
doaj   +1 more source

Organic Anion and Cation Transporter Expression and Function During Embryonic Kidney Development and in Organ Culture Model Systems [PDF]

, 2006
Background Organic anion and cation transporters (OATs, OCTs and OCTNs) mediate the proximal tubular secretion of numerous clinically important compounds, including various commonly prescribed pharmaceuticals.
Bush, Kevin T., Eraly, Satish A., Nigam, Sanjay K., Sweet, Douglas H.   +3 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mutatis mutandis: Are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report

The Turkish Journal of Gastroenterology, 2014
We report three patients presenting with gluten-related signs and symptoms. Since villous height/crypt depth ratio, intraepithelial lymphocyte count, and serum antibody tests were not diagnostic for celiac disease (CD), a diagnosis of non-celiac gluten ...
Raffaele Borghini, Giuseppe Donato, Marco Di Tola, Claudia Isonne, Antonio Picarelli   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Fetal Skin Organ Culture

Journal of Investigative Surgery, 1990
The fetal response to cutaneous injury has been investigated in a variety of models; most have studied the differences between fetal and adult healing mechanisms in vivo and in cell culture. Further disclosure of the cellular and biochemical events requires a model that can be manipulated to study single factors influencing fetal tissue repair without ...
J H, Haynes, T M, Krummel, L C, Flood, I K, Cohen, R F, Diegelmann   +4 more
openaire   +2 more sources