The pipe organ in twentieth-century Great Britain, with specific focus on the development and effects of the neo-classical organ [PDF]
, 2004 From as early as the 1920s the romantic English organ became the target of much criticism, specifically amongst Europeans. Albert Schweitzer, for example, had questioned the organ's suitability for the performance of Bach's organ works, deploring its ...
Atherton, Matthew Stuart
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Graphical Abstract. Autologous iPSC-derived four-organ-chip
, 2019 Microphysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents.
Lin, Grace (7363457) +17 more
core +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Review for special issue: Corneal lamellar surgery: Present outcomes and future perspectives
Taiwan Journal of OphthalmologySince the establishment of the first eye bank in the 1940s, their role has evolved to face new challenges. With the recent development of lamellar keratoplasties, eye banks play an even bigger role in the selection and preparation of donor tissues.
Loïc Hamon +6 more
doaj +1 more source
Immune Mediated Degeneration and Possible Protection in Glaucoma
Frontiers in Neuroscience, 2019 The underlying pathomechanisms for glaucoma, one of the most common causes of blindness worldwide, are still not identified. In addition to increased intraocular pressure (IOP), oxidative stress, excitotoxicity, and immunological processes seem to play a
Teresa Tsai +3 more
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits [PDF]
, 2008 Background: In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they
Markku Maki +31 more
core +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Dopamine Has a Critical Role in Photoreceptor Degeneration in the rd Mouse
Neurobiology of Disease, 2002 Photoreceptors receive paracrine input from dopaminergic interplexiform cells. Rod photoreceptors in the rd mouse degenerate rapidly due to a specific gene defect.
Judith Mosinger Ogilvie, Judith D. Speck
doaj +1 more source
Clavierists at the Organ in 18th Century Sweden : Jonas Lundblad plays the 1783 organ at Dala-Husby
, 2020 Explores the repertoire and performance practice of Swedish keyboard players at the organ in the latter half of the 18th century. Goes beyond the few extant original works specifically for the organ and includes transcriptions as well as keyboard pieces ...
Lundblad, Jonas,
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