Results 41 to 50 of about 143,457 (296)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Eligible DBD Donors Proceeding via the DCD Pathway: Incidence, Cause, and Outcomes in the United Kingdom

Transplantation Direct
Background. Eligible donation after brain death (DBD) donors may rarely proceed via the donation after circulatory death (DCD) pathway. The incidence, reasons for pathway divergence, and graft and recipient outcomes in the United Kingdom of this cohort ...
Mark Burgess, MBChB, MSc, FRCA, FFICM, MRCP, Laura Silsby, BSc, Susanna Madden, MSc, Joana Da Silva Letra, RN, Stephanie Thomson, Diploma in Nursing, Janine Tate, BSc, Diploma in Intensive Care, Sharon Mitchinson, Diploma in Nursing, Katherine Hurley, BSc, Rebecca Hurley, BSc, Marco Bon, Diploma in Nursing, Rachel Pritchard, BSc, Sue Duncalf, BSc, Dale Gardiner, MBBS, MBioEth, FFICM   +12 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Perfusion-induced renal hardness measured by Shore durometer: a novel, low-cost biomarker of donor kidney quality

Renal Failure
Quantitative assessment of donor kidney quality remains challenging in transplantation medicine. This study investigated the correlation between Shore durometer-measured renal hardness and established quality indicators (hypothermic machine perfusion ...
Guozhen Chen, Haiping Liu, Fan Wang, Chenguang Ding, Wujun Xue   +4 more
doaj   +1 more source

Ischaemia-free liver transplantation in humans: a first-in-human trial

The Lancet Regional Health. Western Pacific, 2021
Summary: Background Ischaemia-reperfusion injury is considered an inevitable component of organ transplantation, compromising organ quality and outcomes. Although several treatments have been proposed, none has avoided graft ischaemia and its detrimental
Zhiyong Guo, M.D., Ph.D., Qiang Zhao, M.D., Ph.D., Shanzhou Huang, M.D., Ph.D., Changjun Huang, M.D., Dongping Wang, M.D., Ph.D., Lu Yang, M.D., Ph.D., Jian Zhang, M.Sc., Maogen Chen, M.D., Ph.D., Linwei Wu, M.D., Ph.D., Zhiheng Zhang, M.D., Zebin Zhu, M.D., Ph.D., Linhe Wang, M.D., Caihui Zhu, M.D., Yixi Zhang, M.D., Ph.D., Yunhua Tang, M.D., Ph.D., Chengjun Sun, M.D., Wei Xiong, M.D., Yuekun Shen, M.D., Ph.D., Xiaoxiang Chen, M.D., Jinghong Xu, M.D., Tielong Wang, M.D., Yi Ma, M.D., Ph.D., Anbin Hu, M.D., Ph.D., Yinghua Chen, M.D., Ph.D., Xiaofeng Zhu, M.D., Ph.D., Jian Rong, M.D., Ph.D., Changjie Cai, M.D., Ph.D., Fengqiu Gong, M.P.H., Xiangdong Guan, M.D., Ph.D., Wenqi Huang, M.D., Ph.D., Dicken Shiu-Chung Ko, M.D., Ph.D., Xianchang Li, M.D., Ph.D., Stefan G Tullius, M.D., Ph.D., Jiefu Huang, M.D., Ph.D., Weiqiang Ju, M.D., Ph.D., Xiaoshun He, M.D., Ph.D.   +35 more
doaj   +1 more source

Organ donation and transplantation - public policy and clinical perspectives [PDF]

, 2012
The book provides specialist information via chapters on public policy as well as clinical developments in organ ...
Randhawa, Gurch
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Evaluating the efficacy of basiliximab versus no induction in low-immunological-risk kidney transplant recipients: a propensity score matched analysis

Renal Failure
Background The optimal use of induction therapy in low-immunological-risk kidney transplant recipients (KTRs) remains uncertain. While Basiliximab (BSX) is widely utilized, its comparative outcomes with no induction therapy require further evaluation ...
Dahao Zhang, Jiqiu Wen, Jianhui Dong, Rong Ma, Shijian Li, Jihua Wu, Ning Wen, Zhiying Lei, Haibin Li, Jun Yin, Xuyong Sun   +10 more
doaj   +1 more source

THE “NEW BODY SNATCHERS”: ANALYZING THE EFFECT OF PRESUMED CONSENT ORGAN DONATION LAWS ON PRIVACY, AUTONOMY, AND LIBERTY [PDF]

, 2011
This Note examines, in three parts, presumed consent laws as they pertain to organ donation. Part I discusses presumed consent and explains the salient features of presumed consent laws.
Liddy, Maryellen
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source