Results 51 to 60 of about 49,997 (313)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The need for increasing the retrieval of organs : doctors’ attitudes towards opting-out [PDF]

, 2010
Some countries have introduced the opting-out system of organ donation as a way of increasing the number of available organs for transplants. Public opinion is divided on this issue and so are medical recommendations.
Lauri, Mary Anne, Zarb Adami, Joseph
core  

The Notion of Gift-Giving and Organ Donation

, 1994
The analogy between gift-giving and organ donation was first suggested at the beginning of the transplantation era, when policy makers and legislators were promoting voluntary organ donation as the preferred procurement procedure.
Gerrand, Nicole
core   +1 more source

New Blood Borne Virus Infections Among Organ Transplant Recipients: A Data-Linked Cohort Study Examining Transmissions and De Novo Infections

International Journal of Population Data Science, 2020
Introduction Solid organ transplant recipients are at risk of infections, which may be either derived through transplantation or acquired later. Blood-borne viruses (BBV) are a particular concern for donor-derived transmissions.
Karen MJ Waller, Nicole L De La Mata, James A Hedley, Brenda M Rosales, Michael J O’Leary, Elena Cavazzoni, Vidiya Ramachandran, William D Rawlinson, Patrick J Kelly, Kate R Wyburn, Angela C Webster   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

They Can't Have My Embryo: The Ethics of Conditional Embryo Donation [PDF]

, 2013
There are substantial numbers of frozen embryos in storage that will not be used by those who produced them for their own fertility treatment. One option for such embryos is to donate them to others to use in their fertility treatment.
Eric Blyth, Lucy Frith, Frith, Lucy; id_orcid, Blyth, Eric, Frith, Lucy   +4 more
core   +1 more source

The First Case of Ischemia-Free Kidney Transplantation in Humans

Frontiers in Medicine, 2019
Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954.
Xiaoshun He, Xiaoshun He, Xiaoshun He, Guodong Chen, Guodong Chen, Guodong Chen, Zebin Zhu, Zebin Zhu, Zebin Zhu, Zhiheng Zhang, Zhiheng Zhang, Zhiheng Zhang, Xiaopeng Yuan, Xiaopeng Yuan, Xiaopeng Yuan, Ming Han, Ming Han, Ming Han, Qiang Zhao, Qiang Zhao, Qiang Zhao, Yitao Zheng, Yitao Zheng, Yitao Zheng, Yunhua Tang, Yunhua Tang, Yunhua Tang, Shanzhou Huang, Shanzhou Huang, Shanzhou Huang, Linhe Wang, Linhe Wang, Linhe Wang, Otto B. van Leeuwen, Xiaoping Wang, Xiaoping Wang, Xiaoping Wang, Chuanbao Chen, Chuanbao Chen, Chuanbao Chen, Liqiu Mo, Xingyuan Jiao, Xingyuan Jiao, Xingyuan Jiao, Xianchang Li, Xianchang Li, Xianchang Li, Xianchang Li, Changxi Wang, Changxi Wang, Changxi Wang, Jiefu Huang, Jiefu Huang, Jun Cui, Zhiyong Guo, Zhiyong Guo, Zhiyong Guo   +56 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source