Results 61 to 70 of about 37,769 (267)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Associations between end stage renal disease and HLA polymorphisms in the Guangxi Zhuang population

Scientific Reports
To investigate the genetic relationship between end stage renal disease (ESRD) and human leukocyte antigen (HLA) alleles in the Guangxi Zhuang population. We performed polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO) in 325
Yongfeng Pei, Haibin Li, Chengxin Huang, Yinhong Qin, Xuyong Sun   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Network meta-analysis of pharmacological treatment for antibody-mediated rejection after organ transplantation

Frontiers in Immunology
ObjectiveThis study aims to assess the efficacy of pharmacological interventions in mitigating graft injury in transplant patients with antibody-mediated rejection (AMR) through a network meta-analysis (NMA).MethodsA search was conducted on databases ...
Junjie Sun, Yanqing Yu, Fu Huang, Fu Huang, Qiuwen Zhang, Lirong Zhu, Guining He, Haibin Li, Xuyong Sun   +8 more
doaj   +1 more source

TO SOME ORGANIZATIONAL ASPECTS OF ORGAN DONATION

Вестник трансплантологии и искусственных органов, 2010
Organization of organ donation for transplantation is one of the most actual problems of Russian Transplantolo- gy. Organ shortage for transplantation is perceiving in Russia through the improvement of organizational system of organ donation. An analysis
M. Minina
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

INFECTIONS IN THE POOL OF POTENTIAL ORGAN DONORS: IS IT ALWAYS CONTRAINDICATION TO DONATION?

Вестник трансплантологии и искусственных органов, 2011
The presence of certain infection in potential organ donors is significant problem for Russian Transplantology. The increase in detection of donor’s infections could be due to increase in general donor’s pool and also to utili- zation of modern ...
M. G. Minina
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Risk factors of delayed kidney graft function following donation after circulatory death – a retrospective cohort study of Swiss kidney transplants

Swiss Medical Weekly
AIMS OF THE STUDY: On 1 September 2011, donation after circulatory death (DCD) organ donation resumed in Switzerland after the DCD programme had been suspended for four years due to jurisdictional and medico-ethical discrepancies.
Maurice Bischof, Simon Schwab, Julius Weiss, Franziska Beyeler, Christian Brunner, Sabine Camenisch, Raphaël Giraud, Yvonne Hilpertshauser, Matthias Peter Hilty, Marco Rusca, Kai Tisljar, Thomas Müller, Franz Immer   +12 more
doaj   +1 more source