Results 61 to 70 of about 687,760 (261)
Gut microbiota-dependent protection by Lactobacillus reuteri against renal injury in brain-dead rats
Scientific ReportsDonation-after-brain-death (DBD) serves as a major source of kidney transplant donors, and brain death (BD) induces systemic inflammation and gut barrier disruption, leading to renal injury and compromised organ quality.
Tao Liu +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The need for increasing the retrieval of organs : doctors’ attitudes towards opting-out [PDF]
, 2010 Some countries have introduced the opting-out system of organ donation as a way of increasing the number of available organs for transplants. Public opinion is divided on this issue and so are medical recommendations.
Lauri, Mary Anne, Zarb Adami, Joseph
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Impact of Presumed Consent Legislation on Cadaveric Organ Donation: A Cross Country Study [PDF]
In the U.S., Great Britain, and in many other countries, the gap between the demand and the supply of human organs for transplantation is on the rise, despite the efforts of governments and health agencies to promote donor registration. In some countries
Alberto Abadie, Sebastien Gay
core
Required Request for Organ Donation: Moral, Clinical, and Legal Problems
, 1988 In recent years, the Uniform Anatomical Gift Act, premised on the authority of individual choice for or against donation, has been widely viewed as inadequate to meet the needs of the growing number of potential organ recipients.
Clark, Leo +2 more
core +1 more source
They Can't Have My Embryo: The Ethics of Conditional Embryo Donation [PDF]
, 2013 There are substantial numbers of frozen embryos in storage that will not be used by those who produced them for their own fertility treatment. One option for such embryos is to donate them to others to use in their fertility treatment.
Eric Blyth +4 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Associations between end stage renal disease and HLA polymorphisms in the Guangxi Zhuang population
Scientific ReportsTo investigate the genetic relationship between end stage renal disease (ESRD) and human leukocyte antigen (HLA) alleles in the Guangxi Zhuang population. We performed polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO) in 325
Yongfeng Pei +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source