Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]
, 2005 The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia +18 more
core
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells [PDF]
, 2002 Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating β-catenin levels in the Wnt signaling pathway, the APC protein is ...
Mackie, John B. +4 more
core +5 more sources
Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons [PDF]
, 2015 During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or function, whereas the same manipulations in mature animals have little or no effect on the same ...
Hume, Clifford +8 more
core +2 more sources
Maturation of NaV and KV channel topographies in the auditory nerve spike initiator before and after developmental onset of hearing function [PDF]
, 2016 Auditory nerve excitation and thus hearing depend on spike-generating ion channels and their placement along the axons of auditory nerve fibers (ANFs).
Kim, Kyunghee X, Rutherford, Mark A
core +2 more sources
Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling
eLife, 2015 The sensory and supporting cells (SCs) of the organ of Corti are derived from a limited number of progenitors. The mechanisms that regulate the number of sensory progenitors are not known.
Sung-Ho Huh +2 more
doaj +1 more source
Organ of Corti Potentials and the Motion of the Basilar Membrane [PDF]
, 2004 Anders Fridberger +6 more
openalex +1 more source
PLoS Genetics, 2019 The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation.
Lu M Yang +3 more
doaj +1 more source
Neural Plasticity, 2018 Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles ...
Shaofeng Liu +10 more
doaj +1 more source
Data for: Organ of Corti vibrations are dominated by longitudinal motion in vivo
, 2022 Sebastiaan W. F. Meenderink
openalex +1 more source