Results 91 to 100 of about 13,741 (226)

Location-dependent organ of corti mechanics in the mammalian cochlea

, 2016
Thesis (Ph. D.)--University of Rochester. Department of Mechanical Engineering, 2016.The mammalian cochlea is the snail-shaped, fluid-filled hearing organ that encodes sound into frequency components and converts sound signal to neural or electrochemical
Gracewski, Sheryl Marie, Nam, Jong-Hoon, Liu, Yanju   +2 more
core  

Epithelial supporting cells can differentiate into outer hair cells and Deiters' cells in the cultured organ of Corti [PDF]

, 2002
peer reviewedThe organ of Corti is a complex structure containing a single row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs), supported respectively by one row of inner phalangeal cells and three rows of Deiters' cells.
Lefebvre, Philippe, Thiry, Marc, Malgrange, Brigitte, Nguyen, Laurent, Thiry, M, Lefebvre, P. P, Nguyen, L, Moonen, G, Malgrange, B, Van de Water, T. R, Van De Water, Thomas R., Moonen, Gustave   +11 more
core   +1 more source

Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

eLife, 2015
The sensory and supporting cells (SCs) of the organ of Corti are derived from a limited number of progenitors. The mechanisms that regulate the number of sensory progenitors are not known.
Sung-Ho Huh, Mark E Warchol, David M Ornitz   +2 more
doaj   +1 more source

Differences in the distribution of F-actin in outer hair cells along the organ of Corti [PDF]

, 1987
There is evidence of differences in the structure, innervation and physiological responses between outer hair cells (OHCs) of the basal and apical turns of the mammalian cochlea. In this study we have used rhodamine-labelled phalloidin to investigate the
Altschuler, Richard A., Schacht, Jochen, Carlisle, Lynn, Thorne, Peter R., Zajic, Gary   +4 more
core   +1 more source

IGF-1 Mediated Neuroprotective Effects of Olfactory-Derived Mesenchymal Stem Cells on Auditory Hair Cells

Journal of Otolaryngology - Head and Neck Surgery
Importance Mesenchymal stem cells (MSCs) have the capability of providing ongoing paracrine support to degenerating tissues. Since MSCs can be extracted from a broad range of tissues, their specific surface marker profiles and growth factor secretions ...
Marc J. W. Lammers MD, PhD, Emily Young MD, Anat Yanai PhD, Ishaq A. Viringipurampeer PhD, Trung N. Le MD, PhD, Louise V. Straatman MD, PhD, Brian D. Westerberg MD, FRCSC, MHSc, Kevin Gregory-Evans MD, PhD, FRCSC   +7 more
doaj   +1 more source

Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner.

PLoS Genetics, 2019
The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation.
Lu M Yang, Kathryn S E Cheah, Sung-Ho Huh, David M Ornitz   +3 more
doaj   +1 more source

The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns

Neural Plasticity, 2018
Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles ...
Shaofeng Liu, Yunfeng Wang, Yongtian Lu, Wen Li, Wenjing Liu, Jun Ma, Fuqin Sun, Mao Li, Zheng-Yi Chen, Kaiming Su, Wenyan Li   +10 more
doaj   +1 more source

Neurog1 expression in organ of Corti cells affects afferent and efferent innervation.

, 2012
In E18.5 wild-type mice, Sox2 is present in the GER and in all supporting cells (a) and many radial fibers project to inner hair cells. Anti-Tubulin antibody labeling shows Type II fibers projecting in a regular pattern to outer hair cells (a’) between ...
Ning Pan (186987), Jeremy S. Duncan (187006), Jennifer Kersigo (186991), Ken A. Morris (186999), Benjamin Kopecky (187003), Israt Jahan (130375), Bernd Fritzsch (93262), Lilian E. Calisto (186995), Kirk W. Beisel (187012)   +8 more
core   +1 more source

The organ of Corti of the mouse.

, 2012
Labelling for all figures: OHC = outer hair cell, IHC = inner hair cell; Dc = Deiters' cell, ip = inner pillar cell, op = outer pillar cell, Hc = Hensen's cell, Cc = Claudius cell, Bc = Boettcher's cell, os = outer sulcus, iph = inner phalangeal cell; ib 
Andrew Forge (4688), Daniel J. Jagger (186043), Ruth R. Taylor (186041)   +2 more
core   +1 more source

Age-related degeneration of the organ of Corti in two genotypes of mice

, 1994
Degenerative changes in the organ of Corti were investigated in two genotypes of mice, CBA/Ca (moderate age-related late-onset hearing loss) and C57BL/6J (spontaneous early-onset auditory deterioration), ranging in age from 1 to 21 months (C57BL) and ...
Li, HS, Hultcrantz, M
core   +1 more source