Results 91 to 100 of about 36,422 (226)

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Taxonomic and functional diversity of noctuoid moths in a Mediterranean coastal area: implications for dune conservation in a long‐term ecological research eLTER site

Insect Science, EarlyView.
This study investigates the taxonomic and functional diversity of noctuoid moths in a protected coastal dune system in Central Italy, revealing strong ecological associations between moth assemblages and dune zonation. Differences in species composition and trait attributes, along with the presence of habitat‐exclusive species, highlight the role of ...
Micaela del Valle Rasino, Simone Fattorini, Michele Innangi, Angela Stanisci, Andrea Sciarretta, Maria Laura Carranza   +5 more
wiley   +1 more source

Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing

Neurobiology of Disease, 2015
Mutations in the Gjb2 gene, which encodes a gap junction protein connexin26 (Cx26), are the most prevalent form of hereditary deafness in humans and represent about half of non-syndromic congenital deafness cases in many ethnic populations.
Qing Chang, Wenxue Tang, Yeunjung Kim, Xi Lin   +3 more
doaj   +1 more source

The tympanic covering layer contributes to basilar membrane elasticity potentially influencing human frequency resolution and speech perception

Journal of Anatomy, EarlyView.
In this study we show for the first time that the human basilar membrane contains elastin produced by the so‐called tympanic covering layer. It is believed to play an important functional role in human cochlear tuning, particularly low frequencies linked to our remarkable speech and music perception.
Wei Liu, Claudia Steinacher, Alexander Glueckert, Rudolf Glueckert, Hao Li, Karin Staxäng, Anneliese Schrott‐Fischer, Hanif M. Ladak, Sumit Agrawal, Helge Rask‐Andersen   +9 more
wiley   +1 more source

The roles of Irx3 and Irx5 in mammalian inner ear development [PDF]

, 2013
Iroquois genes encode a family of transcription factors containing TALE class homeodomain. They are regarded as prepatterning genes in Drosophila sensory organ development. There are six members (Irx1Irx6) of Iroquois genes in mouse and human.
Chan, YS, Chu, KH, Hui, CC, Liu, Y, Sham, MH, Wang, B, Wong, YM   +6 more
core  

The cochlear morphometry compendium: High‐resolution synchrotron measurements and normative reference values

Journal of Anatomy, EarlyView.
In this study, 100 cadaveric temporal bones underwent synchrotron radiation phase‐contrast imaging. Images were segmented to produce 3D surface mesh models for morphological analysis. Measurements obtained for all cochleae included: standard gross dimensions, various cochlear lengths including basilar membrane length, detailed intracochlear scalar ...
Sumit K. Agrawal, Hao Li, Carmine Spedaliere, Helge Rask‐Andersen, Hanif M. Ladak   +4 more
wiley   +1 more source

Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]

, 2019
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J., Gale, Jonathan E., Gonçalves, Ana Cláudia, Haq, Naila, Pelletier, Jerry, Porco, John A., Towers, Emily R.   +6 more
core   +2 more sources

Dye coupling in the organ of Corti

Cell and Tissue Research, 1986
Dye-coupling in an in vitro preparation of the supporting cells of the guinea-pig organ of Corti was evaluated by use of the fluorescent dyes, Lucifer Yellow, fluorescein and 6 carboxyfluorescein. Despite the presence of good electrical coupling in Hensen cells (coupling ratios greater than 0.6) the spread of Lucifer yellow was inconsistent.
openaire   +3 more sources

Intraspecific variation of cochlear morphology in bowhead and beluga whales

The Anatomical Record, Volume 309, Issue 6, Page 1514-1529, June 2026.
Abstract The bony labyrinth of the petrosal bone, a distinctive feature of mammal skulls, is often identified in micro‐computed tomography imaging to infer species' physiological and ecological traits. When done as part of a comparative study, one individual specimen is normally considered representative of a species, and intraspecific variation is ...
John Peacock, J. G. M. Thewissen
wiley   +1 more source

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]

, 2005
The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia, Braig, Claudia, Engel, Jutta, Hirt, Bernhard, Knipper, Marlies, Knirsch, Martina, Köpschall, Iris, Langer, Patricia, Müller, Marcus, Münkner, Stefan, Pfaff, Imke, Pfister, Markus, Rohbock, Karin, Ruth, Peter, Rüsch, Alfons, Rüttiger, Lukas, Sausbier, Matthias, Winter, Harald, Zimmermann, Ulrike   +18 more
core