Results 71 to 80 of about 13,741 (226)

Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An, Chen‐Yu Xu, Meng‐Ya Shen, Xiao‐Tao Guo, Chun‐Chen Pan, Jing‐Wu Sun, Xiao‐Min Tang, Jia‐Qiang Sun   +7 more
wiley   +1 more source

Tyrosine hydroxylase immunoreactivity identifies possible catecholaminergic fibers in the organ of Corti [PDF]

, 1987
Antibodies to tyrosine hydroxylase. dopamine [beta]-hydroxylase and phenylethanolamine N-methyltransferase were used in an immunocytochemical examination of catecholamines in the cochlea.
Altschuler, Richard A., Jones, Nancy, Fex, Jorgen   +2 more
core   +1 more source

Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium.

PLoS Genetics, 2017
The organ of Corti in the cochlea is a two-cell layered epithelium: one cell layer of mechanosensory hair cells that align into one row of inner and three rows of outer hair cells interdigitated with one cell layer of underlying supporting cells along ...
Ting Zhang, Jinshu Xu, Pascal Maire, Pin-Xian Xu   +3 more
doaj   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Computational study on the mechano-transduction in the organ of Corti

, 2021
Thesis (Ph. D.)--University of Rochester. Department of Mechanical Engineering, 2021.The cochlea encodes acoustical stimulations into neural signals. The auditory sensory epithelium in the cochlea, called the organ of Corti, consists of sensory receptor ...
Nam, Jong-Hoon, Zhou, Wenxiao
core  

Taxonomic and functional diversity of noctuoid moths in a Mediterranean coastal area: implications for dune conservation in a long‐term ecological research eLTER site

Insect Science, EarlyView.
This study investigates the taxonomic and functional diversity of noctuoid moths in a protected coastal dune system in Central Italy, revealing strong ecological associations between moth assemblages and dune zonation. Differences in species composition and trait attributes, along with the presence of habitat‐exclusive species, highlight the role of ...
Micaela del Valle Rasino, Simone Fattorini, Michele Innangi, Angela Stanisci, Andrea Sciarretta, Maria Laura Carranza   +5 more
wiley   +1 more source

Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro

BMC Neuroscience, 2011
Background Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects.
Brand Yves, Setz Cristian, Levano Soledad, Listyo Alwin, Chavez Eduardo, Pak Kwang, Sung Michael, Radojevic Vesna, Ryan Allen F, Bodmer Daniel   +9 more
doaj   +1 more source

The tympanic covering layer contributes to basilar membrane elasticity potentially influencing human frequency resolution and speech perception

Journal of Anatomy, EarlyView.
In this study we show for the first time that the human basilar membrane contains elastin produced by the so‐called tympanic covering layer. It is believed to play an important functional role in human cochlear tuning, particularly low frequencies linked to our remarkable speech and music perception.
Wei Liu, Claudia Steinacher, Alexander Glueckert, Rudolf Glueckert, Hao Li, Karin Staxäng, Anneliese Schrott‐Fischer, Hanif M. Ladak, Sumit Agrawal, Helge Rask‐Andersen   +9 more
wiley   +1 more source

Organ of Corti

, 2011
Organ of Corti is an experimental instrument that filters the sounds around it into new listening experiences. The piece invokes the disciplines of music; sound, land-, and installation art, acoustic ecology, and acoustics, offering insights in these ...
Prior, David, Crow, Frances
core  

The cochlear morphometry compendium: High‐resolution synchrotron measurements and normative reference values

Journal of Anatomy, EarlyView.
In this study, 100 cadaveric temporal bones underwent synchrotron radiation phase‐contrast imaging. Images were segmented to produce 3D surface mesh models for morphological analysis. Measurements obtained for all cochleae included: standard gross dimensions, various cochlear lengths including basilar membrane length, detailed intracochlear scalar ...
Sumit K. Agrawal, Hao Li, Carmine Spedaliere, Helge Rask‐Andersen, Hanif M. Ladak   +4 more
wiley   +1 more source