Results 51 to 60 of about 13,741 (226)
Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear. [PDF]
PLoS ONE, 2014 Sensory nerves of the brainstem are mostly composed of placode-derived neurons, neural crest-derived neurons and neural crest-derived Schwann cells. This mixed origin of cells has made it difficult to dissect interdependence for fiber guidance. Inner ear-
YanYan Mao +3 more
doaj +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
On time-delayed and feed-forward transmission line models of the cochlea
, 2010 The mammalian cochlea is a remarkable organ that is able to provide up to 60dB amplification of low amplitude sound with sharp tuning. It has been proposed that in order qualitatively to explain experimental data, models of the basilar membrane impedance
Homer, ME +8 more
core +1 more source
The regulation of stem cell fate and its application in neural regeneration
Interdisciplinary Medicine, EarlyView.Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He +3 more
wiley +1 more source
, 2000 peer reviewedThe organ of Corti is highly ordered, with a single row of inner hair cells and three rows of outer hair cells. The number of hair cells produced was thought to be limited by the time of their terminal mitosis (i.e.
Thiry, Marc +9 more
core +1 more source
Journal of Intelligent Medicine, EarlyView.Abstract With global population aging, age‐related hearing loss has become a major public health concern. Understanding the relationship between auditory functional decline and cochlear structural degeneration is essential for early detection and precise intervention.
Shu Zheng +3 more
wiley +1 more source
, 2012 These images of the comparable segments of E18.5 cochlea display expression differences of several genes in and around the organ of Corti for four different mouse genotypes. In situ hybridization of Atoh1 shows a reduced expression in the heterozygous KI
Ning Pan (186987) +8 more
core +1 more source
Use of scanning electron microscopy in the cochlea of guinea pigs
Brazilian Journal of Otorhinolaryngology, 2020 Introduction: The use of electron microscopy in the study of the inner ear has allowed us to observe minute details of the hair cells, especially in ototoxicity studies; however, the preparation of this material is a difficult and delicate task.
Luiz César Nakao Iha +1 more
doaj +1 more source
The Laryngoscope, EarlyView.Otogenic route of meningitis was associated with greater cochlear hair cell loss in comparison with the meningogenic one in this otopathology study. Neuronal depletion has been traditionally implicated in failed hearing rehabilitation of post‐meningitis deafness.
Matheus Pedrosa Tavares +5 more
wiley +1 more source
Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice. [PDF]
PLoS ONE, 2015 Tricellular tight junctions seal the extracellular spaces of tricellular contacts, where the vertices of three epithelial cells meet, and are required for the establishment of a strong barrier function of the epithelial cellular sheet.
Tomohito Higashi +3 more
doaj +1 more source