Results 41 to 50 of about 166,078,283 (220)

Mouse Embryonic Fibroblasts-Derived Extracellular Matrix Facilitates Expansion of Inner Ear-Derived Cells [PDF]

Cell Journal, 2023
Objective: Previous reports showed that mouse embryonic fibroblasts (MEFs) could support pluripotent stem cell selfrenewaland maintain their pluripotency.
Junming Zhang, Li Liu, Yuexia Li, Jinglei Wu, Xiangxin Lou   +4 more
doaj   +1 more source

Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

eLife, 2016
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti.
Martin L Basch, Rogers M Brown II, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, Andrew K Groves   +13 more
doaj   +1 more source

Microstructural interactions contribute to the hotspot in the living cochlea

Current Research in Neurobiology, 2022
The mechanism of the active cochlea relies on a complex interaction between microstructures in the organ of Corti. A significant longitudinal vibration “hotspot” was recently observed in the high-frequency region of the living gerbil cochlea between the ...
Junpei Liu, Yanru Bai, Qianli Cheng, Shu Zheng, Stephen Elliott, Guangjian Ni   +5 more
doaj   +1 more source

On time-delayed and feed-forward transmission line models of the cochlea [PDF]

, 2010
The mammalian cochlea is a remarkable organ that is able to provide up to 60dB amplification of low amplitude sound with sharp tuning. It has been proposed that in order qualitatively to explain experimental data, models of the basilar membrane impedance
Homer, ME, Martin Homer, Epp, B, Champneys, AR, Bastian Epp, Szalai, R, Epp, Bastian, Robert Szalai, Alan Champneys   +8 more
core   +1 more source

The Study of Otoacoustic Emissions and the Suppression of Otoacoustic Emissions in Subjects with Tinnitus and Normal Hearing: An Insight to Tinnitus Etiology

International Archives of Otorhinolaryngology, 2015
Introduction Analysis of the suppression effect is a simple method to evaluate cochlear status and central auditory mechanisms and, more specifically, the medial olivocochlear system.
Lucieny Serra, Gabriela Novanta, Andre Lopes Sampaio, Carlos Augusto Oliveira, Ronaldo Granjeiro, Silvia Cristina Braga   +5 more
doaj   +1 more source

Fas Ligand Expression in the Organ of Corti [PDF]

Audiology and Neurotology, 2003
We have previously demonstrated by FACS analysis and histochemistry that Fas ligand (FasL) increases on cochlear cell surfaces after immune response or stimulation with γ-interferon (IFN-γ). To determine whether the appearance of FasL on cochlear cell membranes is related to gene expression or to posttranslational events, cochlear cells were treated ...
Bodmer, Daniel, Brors, Dominik, Bodmer, Morana, Pak, Kwang, Ryan, Allen F.   +4 more
openaire   +3 more sources

Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells

BMJ Open Diabetes Research & Care, 2020
ObjectiveThe mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to ...
Ann-Ki Pålbrink, Franziska Kopietz, Björn Morén, René In 't Zandt, Federico Kalinec, Karin Stenkula, Olga Göransson, Cecilia Holm, Måns Magnusson, Eva Degerman   +9 more
doaj   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation.

Frontiers in Aging Neuroscience, 2015
The innervation of the inner ear critically depends on the two neurotrophins Ntf3 and Bdnf. In contrast to this molecularly well established dependency, evidence regarding the need of innervation for long-term maintenance of inner ear hair cells is ...
Jennifer eKersigo, Bernd eFritzsch
doaj   +1 more source

Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice. [PDF]

PLoS ONE, 2015
Mutations in GJB2, which encodes connexin 26 (Cx26), a cochlear gap junction protein, represent a major cause of pre-lingual, non-syndromic deafness. The degeneration of the organ of Corti observed in Cx26 mutant-associated deafness is thought to be a ...
Takashi Anzai, Ichiro Fukunaga, Kaori Hatakeyama, Ayumi Fujimoto, Kazuma Kobayashi, Atena Nishikawa, Toru Aoki, Tetsuo Noda, Osamu Minowa, Katsuhisa Ikeda, Kazusaku Kamiya   +10 more
doaj   +1 more source