Results 21 to 30 of about 13,741 (226)
Cochlea cell-specific marker expression upon in vitro Hes1 knockdown [PDF]
Brazilian Journal of Medical and Biological Research, 2021 NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from
A.C. Batissoco +9 more
doaj +1 more source
Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation
Redox Report, 2023 Cisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity.
Masahiro Adachi +5 more
doaj +1 more source
Primary Culture and Plasmid Electroporation of the Murine Organ of Corti [PDF]
, 2010 In all mammals, the sensory epithelium for audition is located along the spiraling organ of Corti that resides within the conch shaped cochlea of the inner ear (fig 1).
Mark Parker +5 more
core +1 more source
Organ of Corti Kinematics [PDF]
JARO - Journal of the Association for Research in Otolaryngology, 2003 The internal workings of the organ of Corti and their relation to basilar membrane motion are examined with the aid of a simple kinematic model. It is shown that, due to the lever system embodied in the organ of Corti, there is a significant transformer gain between basilar membrane and cilia displacements.
openaire +2 more sources
MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5
Cell Reports, 2015 The organ of Corti, the auditory organ of the mammalian inner ear, contains sensory hair cells and supporting cells that arise from a common sensory progenitor. The molecular bases allowing the specification of these progenitors remain elusive.
Aurélia Huyghe +9 more
doaj +1 more source
Brazilian Journal of Otorhinolaryngology, 2009 The medial olivocochlear tract has efferent control over the outer hair cells, regulating the slow contractions and damping the fast ones. Using ipsilateral, contralateral or bilateral otoacoustic emissions amplitude studies, it is possible to estimate ...
Jerusa Roberta Massola de Oliveira +2 more
doaj +1 more source
Two passive mechanical conditions modulate power generation by the outer hair cells.
PLoS Computational Biology, 2017 In the mammalian cochlea, small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback of the outer hair cells. The level of amplification is greater in the base than in the apex of the cochlea.
Yanju Liu +2 more
doaj +1 more source
Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
Frontiers in Cell and Developmental Biology, 2021 Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea.
María Beatriz Durán Alonso +10 more
doaj +1 more source
Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1
Cells, 2023 It is widely accepted that cell fate determination in the cochlea is tightly controlled by different transcription factors (TFs) that remain to be fully defined. Here, we show that Sox9, initially expressed in the entire sensory epithelium of the cochlea,
Mona Veithen +8 more
doaj +1 more source
Mouse Embryonic Fibroblasts-Derived Extracellular Matrix Facilitates Expansion of Inner Ear-Derived Cells [PDF]
Cell Journal, 2023 Objective: Previous reports showed that mouse embryonic fibroblasts (MEFs) could support pluripotent stem cell selfrenewaland maintain their pluripotency.
Junming Zhang +4 more
doaj +1 more source