Consequences of Location-Dependent Organ of Corti Micro-Mechanics. [PDF]
PLoS ONE, 2015 The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is
Yanju Liu +2 more
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Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival [PDF]
Frontiers in ImmunologyMacrophages are the primary immune cells in the cochlea, essential for maintaining cochlear homeostasis and orchestrating inflammatory responses to pathological events.
Mengxiao Ye +6 more
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Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers. [PDF]
PLoS ONE, 2012 In the adult mammalian auditory epithelium, the organ of Corti, loss of sensory hair cells results in permanent hearing loss. The underlying cause for the lack of regenerative response is the depletion of otic progenitors in the cell pool of the sensory ...
Jörg Waldhaus +5 more
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Quantitative High-Resolution Cellular Map of the Organ of Corti [PDF]
Cell Reports, 2015 The organ of Corti harbors highly specialized sensory hair cells and surrounding supporting cells that are essential for the sense of hearing. Here, we report a single cell gene expression data analysis and visualization strategy that allows for the ...
Jörg Waldhaus +2 more
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Organ of Corti Kinematics [PDF]
JARO - Journal of the Association for Research in Otolaryngology, 2003 The internal workings of the organ of Corti and their relation to basilar membrane motion are examined with the aid of a simple kinematic model. It is shown that, due to the lever system embodied in the organ of Corti, there is a significant transformer gain between basilar membrane and cilia displacements.
Peter Dallos
exaly +3 more sources
Organ of Corti vibrations are dominated by longitudinal motion in vivo [PDF]
Communications Biology, 2022 Multi-angle optical coherence tomography measurements link organ of Corti vibrations to complex motions in inner-ear sound processing.
Sebastiaan W. F. Meenderink, Wei Dong
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Frontiers in Cellular Neuroscience, 2018 We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and ...
Karen L. Elliott +2 more
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Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro. [PDF]
PLoS ONE, 2016 The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age.
Mohamed Bassiouni +4 more
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Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti [PDF]
Frontiers in Neuroscience, 2023 Tubby-like proteins are membrane-associated adaptors that mediate directional trafficking into primary cilia. In inner ear sensory epithelia, cilia—including the hair cell’s kinocilium—play important roles as organizers of polarity, tissue architecture ...
Laura A. Lindner +3 more
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A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae [PDF]
Scientific ReportsFKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus.
Asuka Sato +3 more
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