In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]
, 2017 We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo +7 more
core +1 more source
Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
Frontiers in Cell and Developmental Biology, 2021 Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea.
María Beatriz Durán Alonso +10 more
doaj +1 more source
Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice [PDF]
, 2019 Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize K+ channels in the primary auditory neurons, the molecular identities of many of these channels and their contributions to hearing ...
Gratton, Michael Anne +11 more
core +5 more sources
Quantitative High-Resolution Cellular Map of the Organ of Corti
Cell Reports, 2015 The organ of Corti harbors highly specialized sensory hair cells and surrounding supporting cells that are essential for the sense of hearing. Here, we report a single cell gene expression data analysis and visualization strategy that allows for the ...
Jörg Waldhaus +2 more
doaj +1 more source
Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1
Cells, 2023 It is widely accepted that cell fate determination in the cochlea is tightly controlled by different transcription factors (TFs) that remain to be fully defined. Here, we show that Sox9, initially expressed in the entire sensory epithelium of the cochlea,
Mona Veithen +8 more
doaj +1 more source
Mouse Embryonic Fibroblasts-Derived Extracellular Matrix Facilitates Expansion of Inner Ear-Derived Cells [PDF]
Cell Journal, 2023 Objective: Previous reports showed that mouse embryonic fibroblasts (MEFs) could support pluripotent stem cell selfrenewaland maintain their pluripotency.
Junming Zhang +4 more
doaj +1 more source
Aminoglycoside-Induced Phosphatidylserine Externalization in Sensory Hair Cells Is Regionally Restricted, Rapid, and Reversible [PDF]
, 2008 The aminophospholipid phosphatidylserine (PS) is normally restricted to the inner leaflet of the plasma membrane. During certain cellular processes, including apoptosis, PS translocates to the outer leaflet and can be labeled with externally applied ...
Gale, Jonathan E +4 more
core +1 more source
Effects of lesions of the organ of corti on hearing [PDF]
Acta Oto-Laryngologica, 2022 Lesions causing changes in the microstructure of the organ of Corti may lead to hearing impairment.The aim of this study was to investigate the effect of various structural lesions on the organ of Corti and the auditory function.A finite element method of the cochlea and the organ of Corti were established based on computed tomography scanning and ...
Wenjuan Yao +5 more
openaire +2 more sources
Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]
, 2015 The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core +1 more source
eLife, 2016 The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti.
Martin L Basch +13 more
doaj +1 more source