Results 31 to 40 of about 166,078,283 (220)
Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. [PDF]
PLoS ONE, 2016 The organ of Corti has evolved a panoply of cells with extraordinary morphological specializations to harness, direct, and transduce mechanical energy into electrical signals.
Lana M Pollock +4 more
doaj +1 more source
Brain Sciences, 2021 We investigated whether treatment with brain-derived neurotrophic factor (BDNF), which is known to protect spiral ganglion cells (SGCs), could also protect hair cells (HCs) and supporting cells (SCs) in the organ of Corti of a guinea pig model of ...
Annamaria Tisi +5 more
doaj +1 more source
Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning
eLife, 2019 The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map
Shinji Urata +7 more
doaj +1 more source
MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5
Cell Reports, 2015 The organ of Corti, the auditory organ of the mammalian inner ear, contains sensory hair cells and supporting cells that arise from a common sensory progenitor. The molecular bases allowing the specification of these progenitors remain elusive.
Aurélia Huyghe +9 more
doaj +1 more source
Tonotopically arranged traveling waves in the miniature hearing organ of bushcrickets [PDF]
, 2012 Place based frequency discrimination (tonotopy) is a fundamental property of the coiled mammalian cochlea. Sound vibrations mechanically conducted to the hearing organ manifest themselves into slow moving waves that travel along the length of the organ ...
Manuela Nowotny (183955) +11 more
core +1 more source
Brazilian Journal of Otorhinolaryngology, 2009 The medial olivocochlear tract has efferent control over the outer hair cells, regulating the slow contractions and damping the fast ones. Using ipsilateral, contralateral or bilateral otoacoustic emissions amplitude studies, it is possible to estimate ...
Jerusa Roberta Massola de Oliveira +2 more
doaj +1 more source
Two passive mechanical conditions modulate power generation by the outer hair cells.
PLoS Computational Biology, 2017 In the mammalian cochlea, small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback of the outer hair cells. The level of amplification is greater in the base than in the apex of the cochlea.
Yanju Liu +2 more
doaj +1 more source
Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
Frontiers in Cell and Developmental Biology, 2021 Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea.
María Beatriz Durán Alonso +10 more
doaj +1 more source
Effects of lesions of the organ of corti on hearing [PDF]
Acta Oto-Laryngologica, 2022 Lesions causing changes in the microstructure of the organ of Corti may lead to hearing impairment.The aim of this study was to investigate the effect of various structural lesions on the organ of Corti and the auditory function.A finite element method of the cochlea and the organ of Corti were established based on computed tomography scanning and ...
Wenjuan Yao +5 more
openaire +2 more sources
Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1
Cells, 2023 It is widely accepted that cell fate determination in the cochlea is tightly controlled by different transcription factors (TFs) that remain to be fully defined. Here, we show that Sox9, initially expressed in the entire sensory epithelium of the cochlea,
Mona Veithen +8 more
doaj +1 more source