Results 31 to 40 of about 13,741 (226)

Effects of lesions of the organ of corti on hearing [PDF]

Acta Oto-Laryngologica, 2022
Lesions causing changes in the microstructure of the organ of Corti may lead to hearing impairment.The aim of this study was to investigate the effect of various structural lesions on the organ of Corti and the auditory function.A finite element method of the cochlea and the organ of Corti were established based on computed tomography scanning and ...
Wenjuan Yao, Lei Gao, Jiangtao Su, Niki Karpeta, Wen Xie, Maoli Duan   +5 more
openaire   +2 more sources

Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

eLife, 2016
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti.
Martin L Basch, Rogers M Brown II, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, Andrew K Groves   +13 more
doaj   +1 more source

Microstructural interactions contribute to the hotspot in the living cochlea

Current Research in Neurobiology, 2022
The mechanism of the active cochlea relies on a complex interaction between microstructures in the organ of Corti. A significant longitudinal vibration “hotspot” was recently observed in the high-frequency region of the living gerbil cochlea between the ...
Junpei Liu, Yanru Bai, Qianli Cheng, Shu Zheng, Stephen Elliott, Guangjian Ni   +5 more
doaj   +1 more source

The Study of Otoacoustic Emissions and the Suppression of Otoacoustic Emissions in Subjects with Tinnitus and Normal Hearing: An Insight to Tinnitus Etiology

International Archives of Otorhinolaryngology, 2015
Introduction Analysis of the suppression effect is a simple method to evaluate cochlear status and central auditory mechanisms and, more specifically, the medial olivocochlear system.
Lucieny Serra, Gabriela Novanta, Andre Lopes Sampaio, Carlos Augusto Oliveira, Ronaldo Granjeiro, Silvia Cristina Braga   +5 more
doaj   +1 more source

Morphological anomalies in the organ of Corti with loss of supporting cell Cx26.

, 2023
(a) (Left) Hematoxylin and eosin stain of a P21 control (Gjb2fl/fl) organ of Corti at high magnification. Hair cell soma are outlined by dashed black lines. (Right) Schematic depicting morphology of hair cells and supporting cells in the control organ of
Calvin J. Kersbergen (16455643), Patrick O. Kanold (3190650), Travis A. Babola (16455646), Dwight E. Bergles (10583489)   +3 more
core   +1 more source

Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells

BMJ Open Diabetes Research & Care, 2020
ObjectiveThe mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to ...
Ann-Ki Pålbrink, Franziska Kopietz, Björn Morén, René In 't Zandt, Federico Kalinec, Karin Stenkula, Olga Göransson, Cecilia Holm, Måns Magnusson, Eva Degerman   +9 more
doaj   +1 more source

Tonotopically arranged traveling waves in the miniature hearing organ of bushcrickets

, 2012
Place based frequency discrimination (tonotopy) is a fundamental property of the coiled mammalian cochlea. Sound vibrations mechanically conducted to the hearing organ manifest themselves into slow moving waves that travel along the length of the organ ...
Manuela Nowotny (183955), Kössl, Manfred, Manuela Nowotny, Arun Palghat Udayashankar, Palghat Udayashankar, Arun, Manfred Kössl, Palghat Udayashankar Arun, Kössl Manfred, Arun Palghat Udayashankar (183949), Manfred Kössl (183953), Nowotny Manuela, Nowotny, Manuela   +11 more
core   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Organ of Corti length.

, 2018
(A) Histogram of the organ of Corti (OC) derived by Hardy and Lee (red) and MHH data (black), (B) Histogram of calculated OC length for MHH data with electrode lengths for FLEX24, FLEX28 and FLEXSoft (+/- 5%).
Andreas Büchner (133117), Omid Majdani (4025570), Max Eike Timm (5900726), Mayra Windeler (5900729), Thomas Lenarz (491685), Rolf Benedikt Salcher (5900732), Tobias Weller (2584729)   +6 more
core   +1 more source

Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation.

Frontiers in Aging Neuroscience, 2015
The innervation of the inner ear critically depends on the two neurotrophins Ntf3 and Bdnf. In contrast to this molecularly well established dependency, evidence regarding the need of innervation for long-term maintenance of inner ear hair cells is ...
Jennifer eKersigo, Bernd eFritzsch
doaj   +1 more source