Results 81 to 90 of about 13,741 (226)
Mutations in the Gjb2 gene, which encodes a gap junction protein connexin26 (Cx26), are the most prevalent form of hereditary deafness in humans and represent about half of non-syndromic congenital deafness cases in many ethnic populations.
Qing Chang +3 more
doaj +1 more source
Adorno's empiricism?: On intellectual and metaphysical experience
Abstract Adorno's work contains pregnant references to the concepts of both “intellectual” and “metaphysical” experience. While the concept of metaphysical experience figures relatively prominently in the Adorno literature, intellectual experience has been largely neglected—indeed to the point that certain scholars have asserted that the two concepts ...
Tom Whyman
wiley +1 more source
The phosphoroorganic modification of Smac‐mimetics (SMs) drives selectivity for cIAP1‐ over XIAP‐BIR3. The divalent SM 6 partially dimerizes cIAP1, whereas it prefers intramolecular binding in XIAP. In XIAP the phosphoroorganic moiety of the monovalent SM 7 functions as an IBM, thus inhibiting both BIR2 and BIR3. Created in BioRender.
Elisa Fagnani +7 more
wiley +1 more source
Dye coupling in the organ of Corti
Dye-coupling in an in vitro preparation of the supporting cells of the guinea-pig organ of Corti was evaluated by use of the fluorescent dyes, Lucifer Yellow, fluorescein and 6 carboxyfluorescein. Despite the presence of good electrical coupling in Hensen cells (coupling ratios greater than 0.6) the spread of Lucifer yellow was inconsistent.
openaire +3 more sources
Abstract Objective Personalized medicine in cochlear implantation has advanced significantly with the advent of software tools that allow for detailed analysis of cochlear anatomy. This facilitates the selection of electrode arrays tailored to the individual cochlear duct length (CDL) and supports anatomy‐based fitting strategies. Concurrently, various
Tobias Rader +4 more
wiley +1 more source
Finite element model of the active organ of Corti
The cochlear amplifier that provides our hearing with its extraordinary sensitivity and selectivity is thought to be the result of an active biomechanical process within the sensory auditory organ, the organ of Corti.
Ni, G. +5 more
core +1 more source
This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Jingyi Xie +14 more
wiley +1 more source
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu +4 more
wiley +1 more source

