Results 101 to 110 of about 1,992,155 (390)
FEBS Open Bio, Volume 15, Issue 4, Page 542-550, April 2025.Co‐crystallization crystallizes a protein with its ligand, resulting in protein–ligand complex crystals. In contrast, soaking introduces a ligand into preformed protein crystals, allowing it to bind. Both methods produce crystals for X‐ray diffraction, which generates diffraction patterns that are analyzed to determine the three‐dimensional structure ...
Barbora Kaščáková +4 more
wiley +1 more source
Protein crystallization and structure determination at room temperature in the CrystalChip
FEBS Open Bio, Volume 15, Issue 4, Page 532-541, April 2025.This protocol describes the implementation of a simple and user‐friendly microfluidic device called CrystalChip that allows the production of crystals by the counter‐diffusion method and their in situ analysis by serial crystallography. As an illustration, it is applied to determine the 3D structure of three proteins from data collected at room ...
Petr Pachl +9 more
wiley +1 more source
Privacy Preserving Architectures for Collaborative Intrusion Detection [PDF]
arXiv, 2016 Collaboration among multiple organizations is imperative for contemporary intrusion detection. As modern threats become well sophisticated it is difficult for organizations to defend with threat context local to their networks alone. Availability of global \emph{threat intelligence} is must for organizations to defend against modern advanced persistent
arxiv
BMC Cancer, 2023 Background Neoadjuvant chemoradiation(nCRT) has been considered the preferred initial treatment strategy for distal rectal cancer. Advantages of this approach include improved local control after radical surgery but also the opportunity for organ ...
Angelita Habr-Gama +13 more
doaj +1 more source
Organ Preservation into the 2020s: The Era of Dynamic Intervention
Transfusion Medicine and Hemotherapy, 2019 Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the ...
A. Petrenko +7 more
semanticscholar +1 more source
Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution [PDF]
, 1993 The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model.
Gasbarrini, A +5 more
core +1 more source
FEBS Open Bio, Volume 15, Issue 4, Page 661-673, April 2025.Compared to normal tissues, NPC1 expression is significantly elevated in hepatocellular carcinoma tissues. Our findings indicate that NPC1 plays a key role in regulating neutrophil recruitment within the tumor, which is a critical factor in the progression of hepatocellular carcinoma and is closely linked to poor patient outcomes.
Songhai Yang +3 more
wiley +1 more source
Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells
FEBS Open Bio, Volume 15, Issue 4, Page 634-646, April 2025.Dexmedetomidine decreases insulin release and affects glucose metabolism; however, the specific mechanism remains largely unknown. This study shows clinically relevant doses of dexmedetomidine suppressed glucose‐stimulated insulin secretion. There was no significant difference in oxygen consumption rate, intracellular ATP levels, or caspase‐3/7 ...
Munenori Kusunoki +5 more
wiley +1 more source
Continual Learning for Abdominal Multi-Organ and Tumor Segmentation [PDF]
arXiv, 2023 The ability to dynamically extend a model to new data and classes is critical for multiple organ and tumor segmentation. However, due to privacy regulations, accessing previous data and annotations can be problematic in the medical domain. This poses a significant barrier to preserving the high segmentation accuracy of the old classes when learning ...
arxiv
Principles and current status of abdominal organ preservation for transplantation
Surgery in Practice and Science, 2020 Solid organ transplantation provides a definitive treatment for end-stage organ failure. The clinical field has progressed rapidly since its early beginnings during the latter half of the 20th century due to advances in the understanding of ...
Syed Hussain Abbas, BM, BMedSci, MRCSEd +1 more
doaj