Results 21 to 30 of about 18,797 (261)

Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation

Frontiers in Pharmacology, 2021
Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and improving graft quality and recipient prognosis are still goals pursued by the transplant community.
Min Cao, Guoqing Wang, Hongli He, Ruiming Yue, Yong Zhao, Lingai Pan, Weiwei Huang, Yang Guo, Tao Yin, Lina Ma, Dingding Zhang, Xiaobo Huang   +11 more
doaj   +1 more source

Cold Storage Media versus Optisol-GS in the Preservation of Corneal Quality for Keratoplasty: A Systematic Review

Applied Sciences, 2022
Optisol-GS is the most widely used pharmaceutical composition to preserve corneas for transplantation. This systematic review investigated the effects of different cold corneal storage media (CCSM) compared with Optisol-GS on the quality of stored ...
Izabela Gimenes, Andréa V. Braga Pintor, Mariana da Silva Sardinha, Guido A. Marañón-Vásquez, Marcelo Salabert Gonzalez, Octavio Augusto França Presgrave, Lucianne Cople Maia, Gutemberg Gomes Alves   +7 more
doaj   +1 more source

Gluconate-Lactobionate-Dextran Perfusion Solutions Attenuate Ischemic Injury and Improve Function in a Murine Cardiac Transplant Model

Cells, 2022
Static cold storage is the cheapest and easiest method and current gold standard to store and preserve donor organs. This study aimed to compare the preservative capacity of gluconate-lactobionate-dextran (Unisol) solutions to histidine-tryptophan ...
Yinan Guo, Franka Messner, Sarah E. Beck, Marcos Iglesias Lozano, Hubert Schwelberger, Yichuan Zhang, Kai Kammers, Byoung Chol Oh, Elizabeth D. Greene, Gerald Brandacher, Kelvin G. M. Brockbank   +10 more
doaj   +1 more source

Melatonin in preservation solutions prevents ischemic injury in rat kidneys.

PLoS ONE, 2022
Transplantation is lifesaving and the most effective treatment for end-stage organ failure. The transplantation success depends on the functional preservation of organs prior to transplantation.
Abdurrahman Coskun, Cumhur Yegen, Serap Arbak, Wafi Attaallah, Omer Gunal, Merve Acikel Elmas, Yasemin Ucal, Ozge Can, Banu Baş, Zeynep Yildirim, Ismail Seckin, Sibel Demirci, Mustafa Serteser, Aysel Ozpinar, Ahmet Belce, Gulcin Basdemir, Derya Emel Moldur, Ecenur Izzete Derelioglu, Tahir Koray Yozgatli, Yigit Erdemgil, Ibrahim Unsal   +20 more
doaj   +1 more source

Development of a Novel Perfusable Solution for ex vivo Preservation: Towards Photosynthetic Oxygenation for Organ Transplantation

Frontiers in Bioengineering and Biotechnology, 2021
Oxygen is the key molecule for aerobic metabolism, but no animal cells can produce it, creating an extreme dependency on external supply. In contrast, microalgae are photosynthetic microorganisms, therefore, they are able to produce oxygen as plant cells
Valentina Veloso-Giménez, Rosalba Escamilla, Rosalba Escamilla, David Necuñir, Rocío Corrales-Orovio, Rocío Corrales-Orovio, Sergio Riveros, Carlo Marino, Carolina Ehrenfeld, Carolina Ehrenfeld, Christian Dani Guzmán, Mauricio P. Boric, Rolando Rebolledo, Rolando Rebolledo, José Tomás Egaña   +14 more
doaj   +1 more source

Comparison of Celsior and Perfadex lung preservation solutions in rat lungs subjected to 6 and 12 hours of ischemia using an ex-vivo lung perfusion system

Clinics, 2012
OBJECTIVE: This study evaluated the performance of lungs that were preserved with different solutions (Celsior, Perfadex or saline) in an ex vivo rat lung perfusion system.
Arteiro Queiroz Menezes, Paulo Manuel Pêgo-Fernandes, Paulo Francisco Guerreiro Cardoso, Karina Andrighetti de Oliveira Braga, Natalia Aparecida Nepomuceno, Rogerio Pazetti, Aristides Tadeu Correia, Mauro Canzian, Jacqueline Klarosk Santim, Fabio Biscegli Jatene   +9 more
doaj   +1 more source

Preservation Solutions for Kidney Transplantation: History, Advances and Mechanisms

Cell Transplantation, 2019
Solid organ transplantation was one of the greatest medical advances during the past few decades. Organ preservation solutions have been applied to diminish ischemic/hypoxic injury during cold storage and improve graft survival.
Yimeng Chen, Jian Shi, Terry C. Xia, Renfang Xu, Xiaozhou He, Ying Xia   +5 more
doaj   +1 more source

Tips for optimizing organ preservation solutions

Acta Biochimica Polonica, 2018
Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism.
Aneta, Ostróżka-Cieślik, Barbara, Dolińska, Florian, Ryszka   +2 more
openaire   +3 more sources

Organ Preservation Solutions in Transplantation: A Literature Review

Experimental and Clinical Transplantation, 2021
Renal transplant with ABO-incompatible donors expands the donor pool. Earlier studies have focused the use of protocol biopsies in ABOincompatible transplant patients. Our study described outcomes of indication (for cause) renal biopsies and clinical outcomes in patients with ABO-incompatible renal transplant.This retrospective study included 164 ...
Samara Guilhermina, de Sousa, Giulia Vitória, Nascimento da Silva, Ana Maria, Costa Rodrigues, Tereza Maria, Meireles Fernandes da Silva, Felipe Cruz, Costa, Amanda, Freitas Teixeira da Silva, Bernardo Felipe, Santana de Macedo, Marcus Vinicius Henriques, Brito   +7 more
openaire   +2 more sources

Revolutionizing deceased donor transplantation: How new approaches to machine perfusion broadens the horizon for organ donation

Transplantation Reports
Solid organ transplantation is lifesaving for persons with end-stage organ disease. Thanks to advancements in organ preservation, surgeons are now able to successfully transplant organs that were previously considered high risk for poor graft function ...
Stephanie Almeida, William Snyder, Mita Shah, Jonathan Fisher, Christopher Marsh, Alana Hawkes, Diana Gorial, Sean DeWolf, Dianne B. McKay   +8 more
doaj   +1 more source