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Correlation of organelle interactions in the development of non-alcoholic fatty liver disease [PDF]

open access: yesFrontiers in Immunology
Organelles, despite having distinct functions, interact with each other. Interactions between organelles typically occur at membrane contact sites (MCSs) to maintain cellular homeostasis, allowing the exchange of metabolites and other pieces of ...
Jiabao Liao   +9 more
doaj   +2 more sources

Impact of Porphyrin Binding to GENOMES UNCOUPLED 4 on Tetrapyrrole Biosynthesis in planta

open access: yesFrontiers in Plant Science, 2022
Plant tetrapyrrole biosynthesis (TPS) provides the indispensable chlorophyll (Chl) and heme molecules in photosynthetic organisms. Post-translational mechanisms control the enzymes to ensure a balanced flow of intermediates in the pathway and synthesis ...
Vincent Fölsche   +5 more
doaj   +1 more source

Brain Ultrastructure: Putting the Pieces Together

open access: yesFrontiers in Cell and Developmental Biology, 2021
Unraveling the fine structure of the brain is important to provide a better understanding of its normal and abnormal functioning. Application of high-resolution electron microscopic techniques gives us an unprecedented opportunity to discern details of ...
Patrick C. Nahirney, Marie-Eve Tremblay
doaj   +1 more source

Podophyllotoxin Exposure Affects Organelle Distribution and Functions in Mouse Oocyte Meiosis

open access: yesFrontiers in Cell and Developmental Biology, 2021
Podophyllotoxin (POD) is one of the most characterized lignans that is commonly found in podophyllum, and its preparations and derivatives are widely used in clinical treatment due to strong antitumor and antivirus activities.
Ping-Shuang Lu   +4 more
doaj   +1 more source

Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles

open access: yesFrontiers in Pharmacology, 2022
Opioids are the most widely used analgesics and therefore have often been the focus of pharmacological research. Macrophages are the most plastic cells in the hematopoietic system.
Shaohua Wen   +11 more
doaj   +1 more source

How neurons maintain their axons long-term: an integrated view of axon biology and pathology

open access: yesFrontiers in Neuroscience, 2023
Axons are processes of neurons, up to a metre long, that form the essential biological cables wiring nervous systems. They must survive, often far away from their cell bodies and up to a century in humans.
Gaynor Smith   +3 more
doaj   +1 more source

Molecular mechanism of histone variant H2A.B on stability and assembly of nucleosome and chromatin structures

open access: yesEpigenetics & Chromatin, 2020
Background H2A.B, the most divergent histone variant of H2A, can significantly modulate nucleosome and chromatin structures. However, the related structural details and the underlying mechanism remain elusive to date. In this work, we built atomic models
Junhui Peng   +3 more
doaj   +1 more source

Protection against Toxoplasma gondii cysts in pigs immunized with rROP2 plus Iscomatrix

open access: yesRevista Brasileira de Parasitologia Veterinária, 2020
This study aimed to evaluate the humoral immune response in pigs immunized intranasally and intramuscularly with recombinant Toxoplasma gondii rROP2 protein in combination with the adjuvant Iscomatrix. Twelve mixed breed pigs divided into three groups (n=
Ivo Alexandre Leme da Cunha   +7 more
doaj   +1 more source

Current condition of immune response types

open access: yesЛечащий Врач, 2021
The article discloses a modern definition of the immune response. The phylogenesis of immunity constitutes a single system and is an integral part of the development of multicellular microorganisms. The emergence of multicellular organisms contributed to
D. A. Sizov, N. Yu. Rukina
doaj   +1 more source

Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape

open access: yesPlatelets, 2021
Mice and mouse platelets are major experimental models for hemostasis and thrombosis; however, important physiological data from this model has received little to no quantitative, 3D ultrastructural analysis.
Irina Pokrovskaya   +9 more
doaj   +1 more source

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