Results 11 to 20 of about 340,460 (357)
Current Opinion in Cell Biology, 2018 Eukaryotic cells are organized into membrane-bound organelles. These organelles communicate with one another through vesicular trafficking pathways and membrane contact sites (MCSs). MCSs are sites of close apposition between two or more organelles that play diverse roles in the exchange of metabolites, lipids and proteins.
Sarah Cohen +2 more
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Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions [PDF]
Frontiers in Cell and Developmental Biology, 2020 Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis and signaling. In recent years, significant advancements have been made in understanding this classical pathway, revealing new insights into multiple steps of vesicular ...
Lin Zhao +3 more
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Selective autophagy of intracellular organelles: recent research advances
Theranostics, 2021 Macroautophagy (hereafter called autophagy) is a highly conserved physiological process that degrades over-abundant or damaged organelles, large protein aggregates and invading pathogens via the lysosomal system (the vacuole in plants and yeast ...
Wen Li +25 more
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Journal of the American Chemical Society, 2021 Biomembranes constitute a basis for all compartments of live cells, and therefore, the monitoring of their lipid organization is essential for understanding cell status and activity.
Dmytro I Danylchuk +2 more
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Current Protocols in Protein Science, 2006 AbstractThis unit describes strategies for studying the proteomes of organelles, which is one example of targeted proteomics. It relies heavily on previously published units dealing with organelle preparation, protein solubilization, and proteomics techniques. A specific commentary for organelle proteomics is provided.
Lescuyer, Pierre +3 more
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Autophagy, 2020 The structural integrity and functional stability of organelles are prerequisites for the viability and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as ...
R. Yao, C. Ren, Z. Xia, Yong-ming Yao
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Membrane-confined liquid-liquid phase separation toward artificial organelles
Science Advances, 2021 A synthetic protocell with subcompartments was designed to mimic cellular signal processing. As the basic unit of life, cells are compartmentalized microreactors with molecularly crowded microenvironments. The quest to understand the cell origin inspires
Wenjing Mu +5 more
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Bisphenol A Exposure Disrupts Organelle Distribution and Functions During Mouse Oocyte Maturation
Frontiers in Cell and Developmental Biology, 2021 Bisphenol A (BPA) is one of the ubiquitous environmental endocrine disruptors (EEDs). Previous studies have shown that the reproduction toxicity of BPA could cause severe effects on the mammal oocytes and disturb the quality of mature oocytes.
Meng-Hao Pan +7 more
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Frontiers in Cell and Developmental Biology, 2021 Cells prepare for fluctuations in nutrient availability by storing energy in the form of neutral lipids in organelles called Lipid Droplets (LDs). Upon starvation, fatty acids (FAs) released from LDs are trafficked to different cellular compartments to ...
Mike F. Renne, Hanaa Hariri
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Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles
Science, 2020 ER regulates stress granule fission A hallmark of eukaryotic cells is the ability to compartmentalize essential reactions into membrane-bound and membraneless organelles.
Jason E. Lee +4 more
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