Results 51 to 60 of about 340,460 (357)

An organelle knockout [PDF]

open access: yesThe Journal of Cell Biology, 2001
![Graphic][1] Swimming is a problem despite remaining lipid rafts. Kurzchalia/AAAS By knocking out a single gene for caveolin-1, Teymuras Kurzchalia (Max Planck Institute, Dresden, Germany) and colleagues have ablated a special subset of lipid rafts called caveolae.
openaire   +2 more sources

The different facets of organelle interplay—an overview of organelle interactions [PDF]

open access: yesFrontiers in Cell and Developmental Biology, 2015
Membrane-bound organelles such as mitochondria, peroxisomes, or the endoplasmic reticulum (ER) create distinct environments to promote specific cellular tasks such as ATP production, lipid breakdown, or protein export. During recent years, it has become evident that organelles are integrated into cellular networks regulating metabolism, intracellular ...
Schrader, M   +3 more
openaire   +4 more sources

Putting organelles in their place

open access: yeseLife, 2021
Experiments in C. elegans reveal new insights into how the ANC-1 protein helps to anchor the nucleus and other organelles in place.
Ulm, Patricia, Jantsch, Verena
openaire   +5 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Cilia - the prodigal organelle [PDF]

open access: yesCilia, 2012
Cilia are the oldest known cellular organelle, first described in 1675 by Anthony van Leeuwenhoek in protozoa [1]. He described them as 'incredibly thin feet, or little legs, which were moved very nimbly'. The term 'cilium' (Latin for eyelash) was probably first coined by Otto Muller in 1786 [2].
Peter K. Jackson, PL Beales
openaire   +3 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Loss of the Conserved Alveolate Kinase MAPK2 Decouples Toxoplasma Cell Growth from Cell Division

open access: yesmBio, 2020
Mitogen-activated protein kinases (MAPKs) are a conserved family of protein kinases that regulate signal transduction, proliferation, and development throughout eukaryotes. The apicomplexan parasite Toxoplasma gondii expresses three MAPKs.
Xiaoyu Hu   +3 more
doaj   +1 more source

Controllable protein phase separation and modular recruitment to form responsive membraneless organelles

open access: yesNature Communications, 2018
Many intrinsically disordered proteins self-assemble into liquid droplets that function as membraneless organelles. Because of their biological importance and ability to colocalize molecules at high concentrations, these protein compartments represent a ...
Benjamin S. Schuster   +8 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Light-based control of metabolic flux through assembly of synthetic organelles

open access: yesNature Chemical Biology, 2019
To maximize a desired product, metabolic engineers typically express enzymes to high, constant levels. Yet, permanent pathway activation can have undesirable consequences including competition with essential pathways and accumulation of toxic ...
Evan M. Zhao   +7 more
semanticscholar   +1 more source

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