Results 31 to 40 of about 114,242,522 (291)

Rat Organic Anion Transporter 3 and Organic Anion Transporting Polypeptide 1 Mediate Perfluorooctanoic Acid Transport

JOURNAL OF HEALTH SCIENCE, 2007
The mechanism by which perfluorooctanoic acid (PFOA) is transported in the kidney was studied in rats. We hypothesized that some transporters that are expressed in the basolateral and/or brush border membrane of proximal tubular cells mediate the transport of PFOA.
Katakura, Masanori, Kudo, Naomi, Tsuda, Tadashi, Hibino, Yasuhide, Mitsumoto, Atsushi, Kawashima, Yoichi   +5 more
openaire   +2 more sources

Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity [PDF]

Kidney International, 1999
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.Cephaloridine (CER) has been used to elucidate the mechanisms of cephalosporin antibiotic-induced nephrotoxicity. Organic anion transporters have been thought to mediate CER uptake by the proximal tubule.
Takeda, Michio, Tojo, Akihiro, Sekine, Takashi, Hosoyamada, Makoto, Kanai, Yoshikatsu, Endou, Hitoshi   +5 more
openaire   +2 more sources

Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats

Pharmaceutical Biology, 2019
Context: Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia.
Cong Fang, Lanying Chen, Mingzhen He, Yingying Luo, Mengjing Zhou, Ni Zhang, Jinfeng Yuan, Huiling Wang, Yongyan Xie   +8 more
doaj   +1 more source

The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1. [PDF]

Am J Physiol Renal Physiol, 2016
Human organic anion transporter 1 (hOAT1), expressed at the basolateral membrane of kidney proximal tubule cells, mediates the active renal secretion of a diverse array of clinically important drugs, including anti-human immunodeficiency virus therapeutics, antitumor drugs, antibiotics, antihypertensives, and anti-inflammatories.
Xu D, Wang H, Gardner C, Pan Z, Zhang PL, Zhang J, You G.   +6 more
europepmc   +3 more sources

Inhibition of the Hepatic Uptake of ^99mTc-Tetrofosmin Using an Organic Cation Transporter Blocker

Pharmaceutics, 2021
The accumulation of high levels of 99mTc-tetrofosmin (99mTc-TF) in the hepatobiliary system can lead to imaging artifacts and interference with diagnosis.
Kodai Nishi, Masato Kobayashi, Minori Kikuchi, Asuka Mizutani, Yuka Muranaka, Ikumi Tamai, Keiichi Kawai, Takashi Kudo   +7 more
doaj   +1 more source

In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters

Molecules, 2019
APINACA (known as AKB48, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide), an indazole carboxamide synthetic cannabinoid, has been used worldwide as a new psychoactive substance.
Sunjoo Kim, Won-Gu Choi, Mihwa Kwon, Sowon Lee, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Im-Sook Song, Hye Suk Lee   +8 more
doaj   +1 more source

Genistein ameliorates hyperuricemia-associated nephropathy in hyperuricemic mice

Food and Agricultural Immunology, 2021
Hyperuricemia is a metabolic disease caused by excessive production of uric acid (UA), which can cause gout, hypertension, hyperlipidemia and other diseases.
Bi Wei-Yun, Zhu Cailin
doaj   +1 more source

SLC2A9 is a high-capacity urate transporter in humans [PDF]

, 2008
Background Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have
Doblado M, Kumari, Meena, Charchar, Fadi J, Samani, NJ, Elliott Paul, Kooner J, M. Marmot (7611368), Eyheramendy S, Dobson Richard J, Marmot, Michael, Connell, JM, Philip Howard, Caulfield, Mark J., J. Chambers (3846385), Connell John M, Munroe, Patricia B, John Chambers, Marmot Michael, Dobson, RJ, Charchar Fadi J, Doblado, M, Kumari, M, Morris Brown, Dobson RJ, Elliott, Paul, Gudrun Veldre, R. J. Dobson (7602557), Caulfield MJ, Iacone, Roberto, Laan, Maris, Lathrop, G. Mark, A. Dominiczak (7611551), Kooner, Jaspal, P. Strazzullo (7611365), Farrall Martin, Viigimaa Margus, Brown, M, Samani, Nilesh J., Francesco P Cappuccio, Lann, Maris, P. Howard (7611350), Nilesh J. Samani (7579793), Farrall, M, K. H. Moley (7611569), Newhouse, Stephen J, Munroe PB, Veldre, Gudrun, Wallace Chris, Evans, S, Chambers, John, Howard P, Martin Farrall, Deb O'Neill, Witkowska K, Newhouse, SJ, M. Laan (7602659), Maris Laan, Charchar FJ, Munroe Patricia B, M. Viigimaa (7602620), Cheeseman C., Dominiczak A, M. Doblado (7611566), Evans Sarah, Onipinla A, Shaw-Hawkins Sue, Lathrop GM, Evans, Sarah, Iacone Roberto, Marmot, M, C. Wallace (7602467), Munroe, PB, Witkowska, K, Wallace, C, M. Farrall (6522599), Moley, KH, Charchar, Fadi J., Brunner E, Eric Brunner, Chris Wallace, Brunner Eric, G. M. Lathrop (7611353), O'Neill, D, Dobson, Richard J., G Mark Lathrop, Richard J Dobson, F. J. Charchar (7591784), Howard Philip, Cappuccio FP, Cappuccio, Francesco, Evans S, E. Brunner (7611371), Lathrop, GM, S. Shaw-Hawkins (7602380), Org Elin, Chambers John, Moley, Kelle Harbert, F. P. Cappuccio (7611356), Wallace, Chris, Connell, J. M. C., Cheeseman, Chris, Sue Shaw-Hawkins, Stephen J Newhouse, Dobson, Richard, Samani NJ, Kelle H Moley, Patricia B Munroe, Howard, P, Wallace C, Cappuccio Francesco P, Veldre Gudrun, Caulfield Mark J, Manuel Doblado, Moley Kelle H, Elin Org, Viigimaa, M, S. J. Newhouse (7602371), Onipinla, Abiodun, Michael Marmot, Elliot, Paul, Dominiczak, A, Veldre G, R. Iacone (7611362), Abiodun Onipinla, Mark J Caulfield, Sarah Evans, Marmot M, Cheeseman Chris, Kooner, J, Brown Morris, J. Kooner (7609340), Laan, M, Moley, Kelle H, Witkowska Kate, Moley, Kelle H., C. Ji (7611359), Shaw Hawkins, Sue, Kumari Meena, P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Pasquale Strazzullo, Laan M, D. O'Neill (7611560), Brown, M. J. (Morris Jonathan), Shaw-Hawkins, Sue, Chris Cheeseman, Samani, Nilesh J, Strazzullo, P, Dobson, Richard; id_orcid, Cappuccio, Francesco P., K. Witkowska (7611563), Munroe, Patricia B., Cappucio, Francesco P., Charchar, FJ, Brunner, Eric, Newhouse SJ, Witkowska, Kate, Kate Witkowska, O'Neill, Deb, Moley KH, Elliott, P, Org, E, Lathrop G. Mark, Paul Elliott, E. Org (7602644), O'Neill Deb, Doblado Manuel, Caulfield, Mark, Marmot, Michael G., John M Connell, Onipinla Abiodun, Caulfield, MJ, Org E, J. M. Connell (7602551), Cappuccio, FP, Newhouse, Stephen, Onipinla, A, Susana Eyheramendy, Newhouse, Stephen J., Brown, Morris, Jaspal Kooner, S. Eyheramendy (7611197), Roberto Iacone, Samani Nilesh J, Fadi J Charchar, Shaw Hawkins S, Strazullo, Pasquale, Cheeseman, C, Elliott P, Strazzullo Pasquale, M. Brown (3020991), Ji Chen, Cheeseman, Chris (Christopher I.), Meena Kumari, Chambers, John, MD, Org, Elin, Anna Dominiczak, S. Evans (6370628), Dominiczak Anna, Iacone, R, Dobson, Richard J, Brunner, E, Margus Viigimaa, P. Elliott (1293702), Viigimaa, Margus, Chen Ji, Connell, John M., Farrall M, Eyheramendy, S, M. J. Caulfield (7602383), Connell, John M, O'Neill D, Eyheramendy, Susana, Chambers J, C. Cheeseman (7611572), Laan Maris, Newhouse Stephen J, Caulfield, Mark J, Ji, C, Doblado, Manuel, Shaw-Hawkins, S, Dominiczak, A. F., Ji C, G. Veldre (7602656), Lathrop, G Mark, Eyheramendy Susana, A. Onipinla (7602377), Cappuccio, Francesco P, M. Kumari (7602503), Kooner Jaspal, Dominiczak, Anna, Nilesh J Samani, Brown M, Chambers, J, Viigimaa M, Strazzullo, Pasquale, Connell JM, Howard, Philip, Ji, Chen, Kumari M, O'Neill, Deb   +241 more
core   +1 more source

Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid

Pharmaceutics, 2021
We investigated the involvement of drug transporters in the pharmacokinetics of rosmarinic acid in rats as well as the transporter-mediated drug interaction potential of rosmarinic acid in HEK293 cells overexpressing clinically important solute carrier ...
Yun Ju Kang, Chul Haeng Lee, Soo-Jin Park, Hye Suk Lee, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Immunohistochemical studies of organic anion transporters and urate transporter 1 expression in human salivary gland [PDF]

Acta Odontologica Scandinavica, 2012
Various substances including uric acid, organic acids and drugs are transported by organic anion transporters (OATs) in the kidney. In addition, a member of the OAT family, urate transporter 1 (URAT1), is involved in the reabsorption of uric acid from the renal tubule.
Ikarashi, Ryuichi, Shibasaki, Koichi, Yamaguchi, Akira   +2 more
openaire   +2 more sources