Results 21 to 30 of about 114,242,522 (291)
Acta Pharmaceutica Sinica B, 2020 Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body.
Jinghui Zhang, Zhou Yu, Guofeng You
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Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten
International Journal of Molecular Sciences, 2023 Organic anion transporters 1 and 3 (OAT1 and OAT3) play a crucial role in kidney function by regulating the secretion of multiple renally cleared small molecules and toxic metabolic by-products. Assessing the activity of these transporters is essential for drug development purposes as they can significantly impact drug disposition and safety.
Pedro Caetano-Pinto, Simone H. Stahl
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Frontiers in Bioscience-Landmark, 2023 Background: Disorders of purine metabolism are the main cause of hyperuricemia. Current drugs for the treatment of hyperuricemia usually cause a degree of cardiovascular damage.
Zheng-Long Li, Shu-Min Wang, Huan Wang
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Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6) [PDF]
Biochemical Pharmacology, 2011 Flavonoids are conjugated by phase II enzymes in humans to form glucuronidated and sulfated metabolites that are excreted in urine via the kidney. In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with human organic anion transporters 1 (OAT1) and 3 (OAT3) and their potential in attenuating OAT ...
Chi Chun, Wong +4 more
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Current Research in Food Science, 2022 The present study aimed to determine the effects of polysaccharides-riched Prunus mume fruit juice concentrate (PFC) on uric acid (UA) excretion and the gut microbiota in mice with chronic kidney disease (CKD).
Yan Huang +4 more
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Identification of steroid sulfate transport processes in the human mammary gland [PDF]
, 2003 Circulating hormones and local biotransformation of steroid precursors are both sources of estrogen in human mammary tissue. Estrone-3-sulfate (E(1)S) is an important estrogenic form in premenopausal women, and dehydroepiandrosterone sulfate (DHEAS ...
Pizzagalli, F. +11 more
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Current Research in Pharmacology and Drug Discovery, 2023 The high levels of bile acids are a critical factor in hepatorenal syndrome. Organic solute transporter α/β (Ostα/β) participate in bile acids reabsorption in the kidney.
Xiaojuan Zhao +6 more
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Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta [PDF]
, 2002 Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates.
Stallmach, T. +4 more
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Immunohistochemical Localization of Multispecific Renal Organic Anion Transporter 1 in Rat Kidney [PDF]
Journal of the American Society of Nephrology, 1999 Abstract. Renal proximal convoluted tubules have an important role, i.e. , to excrete organic anions, including numerous drugs and endogenous substances. Recently, multispecific organic anion transporter 1 (OAT1) was isolated from rat kidney.
A, Tojo +6 more
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
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