Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions [PDF]
Journal of Xenobiotics, 2023 Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing the
Aaron O. Buaben, Ryan M. Pelis
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Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice [PDF]
Nature Communications, 2022 Chronic pain is sustained by alterations in gene transcription. Here, the authors show that increased expression of Organic Anionic Transporter 1 in the spinal cord is epigenetically controlled and key to hypersensitivity in pathological pain.
Christian Litke +6 more
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Protein kinase C regulates organic anion transporter 1 through phosphorylating ubiquitin ligase Nedd4–2 [PDF]
BMC Molecular and Cell Biology, 2021 Background Organic anion transporter 1 (OAT1) is a drug transporter expressed on the basolateral membrane of the proximal tubule cells in kidneys.
Zhou Yu +4 more
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Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes [PDF]
Scientific Reports, 2022 The human SLC22A6/OAT1 plays an important role in the elimination of a broad range of endogenous substances and xenobiotics thus attracting attention from the pharmacological community.
Angelika Janaszkiewicz +7 more
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Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model [PDF]
Pharmaceutics, 2022 Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional.
Xueyan Gou +4 more
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Molecular characterization of Gyps africanus (African white-backed vulture) organic anion transporter 1 and 2 expressed in the kidney. [PDF]
PLoS ONE, 2021 Gyps species have been previously shown to be highly sensitive to the toxic effects of diclofenac, when present in their food sources as drug residues following use as a veterinary medicine.
Bono Nethathe +3 more
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Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1) [PDF]
Physiological Reports, 2019 Organic anion transporter 1 (OAT1) is a polyspecific transport protein located in the basolateral membrane of renal proximal tubule cells. OAT1 plays a pivotal role in drug clearance.
Anna M. Euteneuer +3 more
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Renal organic anion transporter 1: clinical relevance and the underlying mechanisms in chronic kidney disease [PDF]
BMC NephrologyOrganic anion transporter 1 (OAT1), primarily found in the renal proximal tubule, is essential for the excretion of various uremic toxins that contribute to the onset and progression of chronic kidney disease (CKD).
Changfang You, Jianchun Guo, Yunhao Xun
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Molecules, 2022 The aim of this study is to evaluate the anti-hyperuricemia effect and clarify the possible mechanisms of flavonoids and phenolics of MOL (MOL-FP) in mice.
Xiaowei Luo +14 more
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Viruses, 2021 Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro ...
Kelly Bleasby +7 more
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