Results 1 to 10 of about 108,803 (172)

Physiological and Putative Organic Cation Transporter Expression Response to Alizarin Dye Exposure in Aedes aegypti Mosquitoes [PDF]

Insects
There remains an urgent need for knowledge regarding the molecular and genetic mechanisms in Aedes aegypti to support the fight against mosquito-borne illness, one of these areas being xenobiotic transport.
Naomi R. Kennel, Matthew F. Rouhier
doaj   +2 more sources

Rescue of Misfolded Organic Cation Transporter 3 Variants

Cells, 2022
Organic cation transporters (OCTs) are membrane proteins that take up monoamines, cationic drugs and xenobiotics. We previously reported novel missense mutations of organic cation transporter 3 (OCT3, SLC22A3), some with drastically impacted transport ...
Thomas J. F. Angenoorth, Julian Maier, Stevan Stankovic, Shreyas Bhat, Sonja Sucic, Michael Freissmuth, Harald H. Sitte, Jae-Won Yang   +7 more
doaj   +1 more source

Transport of Drugs and Endogenous Compounds Mediated by Human OCT1: Studies in Single- and Double-Transfected Cell Models

Frontiers in Pharmacology, 2021
Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g.
Bastian Haberkorn, Martin F. Fromm, Jörg König   +2 more
doaj   +1 more source

Kidney‐specific expression of a novel mouse organic cation transporter‐like protein [PDF]

FEBS Letters, 1997
Using the signal sequence trap method, we have cloned a novel 12‐membrane‐spanning transporter‐like protein, termed renal‐specific transporter (RST), from the mouse kidney. RST is a 553‐amino‐acid protein highly homologous to recently cloned organic cation transporters, e.g.
Mori, Kiyoshi, Ogawa, Yoshihiro, Ebihara, Ken, Aoki, Tomohiro, Tamura, Naohisa, Sugawara, Akira, Kuwahara, Takashi, Ozaki, Shoichi, Mukoyama, Masashi, Tashiro, Kei, Tanaka, Issei, Nakao, Kazuwa   +11 more
openaire   +2 more sources

The pharmacogenomics of lamotrigine (a literature review)

Анналы клинической и экспериментальной неврологии, 2021
Pharmacogenomics aims to optimize drug therapy with respect to genetic variations in various human genes, whose products affect drug pharmacokinetics and pharmacodynamics.
Asya M. Azhigova, Amayak G. Broutian, Pavel N. Vlasov   +2 more
doaj   +1 more source

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children [PDF]

Drug Metabolism and Disposition, 2017
Organic cation transporter 1 (OCT1) plays an important role in the disposition of clinically important drugs, and the capacity of OCT1 activity is presumed to be proportional to the protein expression level in organ tissues. Knowledge of OCT1 protein expression in children, especially neonates and small infants, is currently very limited.
David, Hahn, Chie, Emoto, Alexander A, Vinks, Tsuyoshi, Fukuda   +3 more
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Divergent Regulation of OCT and MATE Drug Transporters by Cadmium Exposure

Pharmaceutics, 2021
Coordinated transcellular transport by the uptake via organic cation transporters (OCTs) in concert with the efflux via multidrug and toxin extrusion proteins (MATEs) is an essential system for hepatic and renal drug disposition.
Hong Yang, Shiwei Zhou, Dong Guo, Obinna N. Obianom, Qing Li, Yan Shu   +5 more
doaj   +1 more source

A human transporter protein that mediates the final excretion step for toxic organic cations [PDF]

Proceedings of the National Academy of Sciences, 2005
In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood.
Otsuka, Masato, Matsumoto, Takuya, Morimoto, Riyo, Arioka, Shigeo, Omote, Hiroshi, Moriyama, Yoshinori   +5 more
openaire   +3 more sources

Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability

Asian Journal of Pharmaceutical Sciences, 2020
Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang, Lichun Zhao, Qikun jiang, Yixin Sun, Dongyang Zhao, Mengchi Sun, Zhonggui He, Jin sun, Yang Wang   +8 more
doaj   +1 more source

The mystery of the human proton-organic cation antiporter: One transport protein or many?

Pharmacology & Therapeutics, 2022
About 30% of all small molecular drugs are organic cations (OCs). If these are more or less hydrophilic, they require membrane transporters to pass through biological membranes. Here, the proton-organic cation (H+ OC) antiporter may play a physiologically most relevant role, particularly concerning passage through the blood-brain barrier.
Sachkova, Alexandra, Jensen, Ole, Dücker, Christof, Ansari, Salim, Brockmöller, Jürgen   +4 more
openaire   +3 more sources