Results 11 to 20 of about 108,823 (192)

Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. [PDF]

PLoS ONE, 2015
Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs) that mediate the uptake of a diverse group of drugs and endogenous compounds into cells.
Jana Knop, Shingen Misaka, Katrin Singer, Eva Hoier, Fabian Müller, Hartmut Glaeser, Jörg König, Martin F Fromm   +7 more
doaj   +1 more source

Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K [PDF]

American Journal of Physiology-Renal Physiology, 2019
Hydrochlorothiazide (HCTZ) is the most widely used thiazide diuretic for the treatment of hypertension either alone or in combination with other antihypertensives. HCTZ is mainly cleared by the kidney via tubular secretion, but the underlying molecular mechanisms are unclear.
Jia Yin, David J. Wagner, Bhagwat Prasad, Nina Isoherranen, Kenneth E. Thummel, Joanne Wang   +5 more
openaire   +2 more sources

The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

Bioinorganic Chemistry and Applications, 2022
The biological behavior of the axially unsymmetric antitumor prodrug (OC-6-44)-acetatodiamminedichloridohydroxidoplatinum(IV), 2, was deeply investigated and compared with that of analogous symmetric Pt(IV) complexes, namely, dihydroxido 1 and diacetato ...
Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella   +5 more
doaj   +1 more source

Divergent molecular responses of greater amberjack (Seriola dumerili) to acute salinity stress revealed by comparative transcriptome analysis

Frontiers in Marine Science, 2023
Greater amberjack (Seriola dumerili) is an important commercial fish for its high growth rate and excellent flesh quality. However, its sensitivity to variations of water salinity poses challenges to the cage culture. In this study, the greater amberjack
Yuqi Liu, Yuqi Liu, Yuqi Liu, Yuchen Yang, Yuchen Yang, Ruotong Qin, Yuhao Peng, Yang Huang, Chunhua Zhu, Chunhua Zhu, Guangli Li, Dongneng Jiang, Hongjuan Shi   +12 more
doaj   +1 more source

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance

Pharmaceutics, 2020
The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj   +1 more source

Urinary Excretion of Tetrodotoxin Modeled in a Porcine Renal Proximal Tubule Epithelial Cell Line, LLC-PK1

Marine Drugs, 2017
This study examined the urinary excretion of tetrodotoxin (TTX) modeled in a porcine renal proximal tubule epithelial cell line, LLC-PK1. Time course profiles of TTX excretion and reabsorption across the cell monolayers at 37 °C showed that the amount of
Takuya Matsumoto, Yui Ishizaki, Keika Mochizuki, Mitsuru Aoyagi, Yoshiharu Mitoma, Shoichiro Ishizaki, Yuji Nagashima   +6 more
doaj   +1 more source

Thioacetamide-Induced Acute Liver Injury Increases Metformin Plasma Exposure by Downregulating Renal OCT2 and MATE1 Expression and Function

Biomedicines, 2023
Metformin plasma exposure is increased in rats with thioacetamide (TAA)-induced liver failure. The absorption, distribution, and excretion process of metformin is mainly mediated by organic cation transporters (OCTs) and multidrug and toxin extrusion ...
Hao Zhi, Yidong Dai, Lin Su, Lu Yang, Wenhan Wu, Zehua Wang, Xinyue Zhu, Li Liu, Jiye Aa, Hanyu Yang   +9 more
doaj   +1 more source

Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor. [PDF]

, 2017
About 50% of the world's arable land is strongly acidic (pH ≤ 5). The low pH solubilizes root-toxic ionic aluminium (Al3+) species from clay minerals, driving the evolution of counteractive adaptations in cultivated crops.
Chang, Geoffrey, Doshi, Rupak, Garza, Denisse M, Kochian, Leon V, McGrath, Aaron P, Piñeros, Miguel, Szewczyk, Paul   +6 more
core   +3 more sources

Using Ex Vivo Porcine Jejunum to Identify Membrane Transporter Substrates: A Screening Tool for Early—Stage Drug Development

Biomedicines, 2020
Robust, predictive ex vivo/in vitro models to study intestinal drug absorption by passive and active transport mechanisms are scarce. Membrane transporters can significantly impact drug uptake and transporter-mediated drug–drug interactions can play a ...
Yvonne E. Arnold, Yogeshvar N. Kalia
doaj   +1 more source

Caveolin-1--a novel interacting partner of organic cation/carnitine transporter (Octn2): effect of protein kinase C on this interaction in rat astrocytes. [PDF]

PLoS ONE, 2013
OCTN2--the Organic Cation Transporter Novel family member 2 (SLC22A5) is known to be a xenobiotic/drug transporter. It transports as well carnitine--a compound necessary for oxidation of fatty acids and mutations of its gene cause primary carnitine ...
Magdalena Czeredys, Łukasz Samluk, Katarzyna Michalec, Karolina Tułodziecka, Krzysztof Skowronek, Katarzyna A Nałęcz   +5 more
doaj   +1 more source