Results 231 to 240 of about 25,837 (279)
The Journal of Pharmacology and Experimental Therapeutics, 2001 Previous inhibition studies with taurocholate and cardiac glycosides suggested the presence of separate uptake systems for small "type I" (system1) and for bulky "type II" (system2) organic cations in rat hepatocytes. To identify the transport systems involved in type I and type II organic cation uptake, we compared the organic cation transport ...
van Montfoort, J. E. +5 more
core +5 more sources
Molecular cloning and functional expression of a rabbit renal organic cation transporter
Biochimica Et Biophysica Acta - Biomembranes, 1998 A cDNA encoding an organic cation transporter (rbOCT1) was isolated from rabbit kidney. The cDNA encodes a 554 amino acid protein that is highly homologous to other mammalian organic cation transporters. rbOCT1 mediated 3H-1-methyl-4-phenylpyridinium (3H-
Mark J Dresser +2 more
exaly +2 more sources
Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter
Biochimica Et Biophysica Acta - Biomembranes, 1999 We describe here the cloning and functional characterization of an organic cation transporter from Caenorhabditis elegans (CeOCT1). The CeOCT1 cDNA is 1826 bp long and codes for a protein of 568 amino acids.
Xiang Wu +2 more
exaly +2 more sources
Gender differences in expression of organic cation transporter OCT2 in rat kidney
FEBS Letters, 1999 The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney.
Yumiko Urakami +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Regulation of organic cation transport
Pfl�gers Archiv - European Journal of Physiology, 2004Transport of organic cations (OC) is important for the recycling of endogenous OC and also a necessary step for detoxification of exogenous OC in the body. Even though the identification and characterisation of numerous OC transporters in recent years has allowed the elucidation of molecular mechanisms underlying OC transport, elucidation of the ...
Giuliano, Ciarimboli +1 more
openaire +2 more sources
2003
Over the last 15 years, a number of transporters that translocate organic cations were characterized functionally and also identified on the molecular level. Organic cations include endogenous compounds such as monoamine neurotransmitters, choline, and coenzymes, but also numerous drugs and xenobiotics.
H, Koepsell, B M, Schmitt, V, Gorboulev
openaire +2 more sources
Over the last 15 years, a number of transporters that translocate organic cations were characterized functionally and also identified on the molecular level. Organic cations include endogenous compounds such as monoamine neurotransmitters, choline, and coenzymes, but also numerous drugs and xenobiotics.
H, Koepsell, B M, Schmitt, V, Gorboulev
openaire +2 more sources
Stereoselective Interactions of Organic Cations with the Organic Cation Transporter in OK Cells
Pharmaceutical Research, 1993Recent studies have suggested that certain organic cations, such as pindolol and the diastereomers, quinine and quinidine, may be stereoselectively secreted by the kidney in humans. The goal of this study was to determine if the enantiomers of pindolol, verapamil, and disopyramide and the diastereomers, quinine and quinidine, interact stereoselectively
R J, Ott, K M, Giacomini
openaire +2 more sources
Renal organic cation and nucleoside transport
Biochemical Pharmacology, 2002We previously reported that the rat organic cation transporter rOCT1 could transport the nucleoside analog deoxytubercidin (dTub) (Chen R, Nelson JA. Biochem Pharmacol 2000;60:215-9). The cationic form of dTub (dTub(+)) appeared to be the true substrate of rOCT1. We also reported that although rOCT2 is similar to rOCT1, it does not transport dTub at pH
Chen, R, Jonker, JW, Nelson, JA
openaire +3 more sources
Xenobiotica, 2008
1. Organic cation transporters (OCTs) translocate endogenous (e.g. dopamine) and exogenous (e.g. drugs) substances of cationic nature and, therefore, play an important role in the detoxification of exogenous compounds. This review aims to furnish essential information on OCTs, with an emphasis on pharmacological aspects. 2.
openaire +2 more sources
1. Organic cation transporters (OCTs) translocate endogenous (e.g. dopamine) and exogenous (e.g. drugs) substances of cationic nature and, therefore, play an important role in the detoxification of exogenous compounds. This review aims to furnish essential information on OCTs, with an emphasis on pharmacological aspects. 2.
openaire +2 more sources
Renal Transport of Organic Anions and Cations
Comprehensive Physiology, 2011Abstract Organic anions and cations (OAs and OCs, respectively) comprise an extraordinarily diverse array of compounds of physiological, pharmacological, and toxicological importance. The kidney, primarily the renal proximal tubule, plays a critical role in regulating the plasma concentrations of these organic ...
Ryan M, Pelis, Stephen H, Wright
openaire +2 more sources