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Transport of small organic cations in the rat liver
Naunyn-Schmiedeberg's Archives of Pharmacology, 1996The kidneys and the liver are the principal organs for the inactivation of circulating organic cations. Recently, an organic cation transporter (OCT1) has been cloned from rat kidney. In order to answer the question whether OCT1 is involved also in hepatic uptake of organic cations, the pharmacological characteristics of organic cation transport in ...
F, Martel +6 more
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Organic Cation Transporters in Psychiatric Disorders
2021Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medications for psychiatric disorders, yet they leave the majority of patients without full symptom relief. Therefore, a major research challenge is to identify novel targets for the improved treatment of these disorders.
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Are organic cation transporters capable of transporting prostaglandins?
Naunyn-Schmiedeberg's Archives of Pharmacology, 2005The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.
Stephanie, Harlfinger +4 more
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Genetic and Epigenetic Regulation of Organic Cation Transporters
2021Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 are the subject of intensive research because they mediate the transport of many clinically-relevant drugs such as the antidiabetic agent metformin, the opioid tramadol, and the antimigraine agent sumatriptan.
Charlotte, Kölz +3 more
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Organic Cation Transporters and Nongenomic Glucocorticoid Action
2021Corticosteroid hormones exert powerful influences on neuronal physiology and behavior by activating intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), which act as ligand-gated transcription factors, altering gene expression.
Benton, Kelsey C. +2 more
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Regulation of the human organic cation transporter hOCT1
Journal of Cellular Physiology, 2004AbstractThe human organic cation transporter type 1 (hOCT1) is an important transport system for small organic cations in the liver. Organic cation transporters are regulated by different signaling pathways, but the regulation of hOCT1 has not yet been studied. In this work, we have for the first time investigated the regulation of hOCT1.
Giuliano, Ciarimboli +6 more
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Structural modeling of human organic cation transporters
Computational Biology and Chemistry, 2017Human organic cation transporters (hOCTs) belong to solute carriers (SLC) 22 family of membrane proteins that play a central role in transportation of chemotherapeutic drugs for several clinical and pathological conditions, including cancer and diabetes.
Tikam Chand Dakal +2 more
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Organic Cation Transporters in Brain Catecholamine Homeostasis
2021Catecholamines, including dopamine, norepinephrine, and epinephrine, are modulatory transmitters released from specialized neurons throughout the brain. Collectively, catecholamines exert powerful regulation of mood, motivation, arousal, and plasticity.
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Structure and Function of Renal Organic Cation Transporters
Physiology, 1998Polyspecific transport systems in the kidney mediate the excretion and reabsorption of organic cations. Electrogenic import systems and electroneutral export systems in the basolateral and luminal plasma membranes of proximal renal tubules are involved.
Hermann, Koepsell +3 more
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Molecular Pharmacology of Organic Cation Transporters in Kidney
Journal of Membrane Biology, 1999The homeostasis of endogenous organic cations, such as choline and N P-methylnicotinamide, monoamine neurotransmitters, cationic drugs, such as cimetidine, morphine, quinine and amantadine, and of cationic xenobiotics is controlled by reabsorption and excretion in the small intestine, by metabolic conversion and excretion in the liver, and by ...
H, Koepsell, V, Gorboulev, P, Arndt
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