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Organic Cation Transporter Expression and Function in the CNS
2021The blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) represent major control checkpoints protecting the CNS, by exerting selective control over the movement of organic cations and anions into and out of the CNS compartment. In addition, multiple CNS cell types, e.g., astrocytes, ependymal cells, microglia, contribute to processes
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Interaction of pharmaceutical excipients with organic cation transporters
International Journal of Pharmaceutics, 2017Increasing evidences have shown that many pharmaceutical excipients are not pharmacologically inert but instead have effects on several transport function of uptake and efflux drug transporters. Herein, we investigated whether the excipients frequently used in many drug formulations affect transport function of organic cation transporters (OCTs) that ...
Sirima, Soodvilai +5 more
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Toxicology of Organic Cations and Regulation of Organic Cation Transport in Drosophila melanogaster
2018Insects accumulate various xenobiotics and toxic molecules through feeding and environmental exposure. This study examines the toxicology and regulation of a class of toxic molecules, organic cations, in Drosophila melanogaster. The results of this thesis demonstrate that transepithelial tetraethylammonium (TEA) secretion across the main segment of the
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Cloning and Functional Expression of a Human Liver Organic Cation Transporter
Molecular Pharmacology, 1997Mark J Dresser +2 more
exaly