Results 151 to 160 of about 24,839 (187)

Characterization of regulatory mechanisms and states of human organic cation transporter 2

American Journal of Physiology-Cell Physiology, 2006
Polyspecific organic cation transporters (OCTs) have a large substrate binding pocket with different interaction domains. To determine whether OCT regulation is substrate specific, suitable fluorescent organic cations were selected by comparing their uptake in wild-type (WT) human embryonic kidney (HEK)-293 cells and in HEK-293 cells stably transfected
Biermann, Jürgen, Lang, Detlef, Gorboulev, Valentin, Koepsell, Hermann, Sindic, Aleksandra, Schröter, Rita, Zvirbliene, Aurelija, Pavenstädt, Hermann, Schlatter, Eberhard, Ciarimboli, Giuliano   +9 more
openaire   +4 more sources

Involvement of Rat Organic Cation Transporter 2 in the Renal Uptake of Jatrorrhizine

Journal of Pharmaceutical Sciences, 2013
Jatrorrhizine is a protoberberine alkaloid derived from Coptis chinensis concentrated extremely in rat kidney. In the present study, the involvement of rat organic cation transporter 2 (rOCT2) in the renal uptake of jatrorrhizine in rat was investigated through in vitro and in vivo experiments.
Zhaodan, Tan, Rong, Zhu, Rong, Shi, Jie, Zhong, Yueming, Ma, Changhong, Wang, Xinhong, Wang, Nengneng, Cheng   +7 more
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Interaction of green tea catechins with renal organic cation transporter 2

Xenobiotica, 2015
1. Green tea extract (GTE) and EGCG have previously shown to increase the uptake of MPP+ into Caco-2 cells. However, whether GTE and its derivatives interact with renal basolateral organic cation transporter 2 (Oct2) which plays a crucial role for cationic clearance remains unknown.
Chaliya, Jaiyen, Promsuk, Jutabha, Naohiko, Anzai, Anusorn, Lungkaphin, Sunhapas, Soodvilai, Chutima, Srimaroeng   +5 more
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Cationic Compounds with SARS-CoV-2 Antiviral Activity and Their Interaction with Organic Cation Transporter/Multidrug and Toxin Extruder Secretory Transporters

The Journal of Pharmacology and Experimental Therapeutics, 2021
In the wake of the COVID-19 pandemic, drug repurposing has been highlighted for rapid introduction of therapeutics. Proposed drugs with activity against SARS-CoV-2 include compounds with positive charges at physiologic pH, making them potential targets for the organic cation secretory transporters of kidney and liver, i.e., the basolateral organic ...
Lucy, Martinez-Guerrero, Xiaohong, Zhang, Kimberley M, Zorn, Sean, Ekins, Stephen H, Wright   +4 more
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Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014
Novel antidepressants or treatment strategies that may offer a more rapid onset of action, improved efficacy, and greater tolerability are in desperate need. Because current clinically utilized antidepressants, which target high-affinity transporters for serotonin and norepinephrine, fail to provide satisfactory treatment outcomes for quite a portion ...
Kai, Wang, Siyuan, Sun, Liping, Li, Meijuan, Tu, Huidi, Jiang   +4 more
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Organic cation transporters 2: Structure, regulation, functions, and clinical implications

Drug Metabolism and Disposition
The SLC22A2 gene encodes organic cation transporter 2 (OCT2), which is predominantly expressed in renal proximal tubule cells. OCT2 is critical for the active renal excretion of various cationic drugs and endogenous metabolites. OCT2 expression varies across species, with higher levels in mice and monkeys compared with humans and rats.
Anoud, Ailabouni, Bhagwat, Prasad
openaire   +2 more sources

Basolateral localization of organic cation transporter 2 in intact renal proximal tubules

American Journal of Physiology-Renal Physiology, 2000
The localization of organic cation transporter 2 (OCT2) within renal cells is the subject of considerable controversy, resulting in marked uncertainty as to its function. To resolve this issue, we made an OCT2/green fluorescent protein (GFP) fusion construct (rOCT2-GFP) and determined its localization within Xenopus laevis oocytes and renal cells using
D H, Sweet, D S, Miller, J B, Pritchard
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Expression and localization of organic cation/carnitine transporter OCTN2 in Caco-2 cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003
l-Carnitine is derived both from dietary sources and biosynthesis. Dietary carnitine is absorbed in the small intestine and then distributed to other organs. Previous studies using Caco-2 cells demonstrated that the transport ofl-carnitine in the intestine involves a carrier-mediated system. The purpose of this study was to determine whether the uptake
Ihsan, Elimrani, Karim, Lahjouji, Ernest, Seidman, Marie-Josee, Roy, Grant A, Mitchell, Ijaz, Qureshi   +5 more
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Mechanism of intestinal transport of an organic cation, tributylmethylammonium in Caco-2 cell monolayers

Archives of Pharmacal Research, 2006
Many quaternary ammonium salts are incompletely absorbed after their oral administration and may also be actively secreted into the intestine. However, the underlying mechanism(s) that control the transport of these cations across the intestinal epithelium is not well understood.
Soon-Sun, Hong, Sang-Cherl, Moon, Chang-Koo, Shim   +2 more
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Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2005
We examined the effect of wild-type human adenovirus (Ad5) on choline transport in murine lung epithelia (MLE) and in rodent primary alveolar type II cells. Cells were active in pH-sensitive, reversible transport of choline, a process blocked pharmacologically with phenoxybenzamine, an inhibitor of organic cation transporters (OCT).
Olga L, Miakotina, Marianna, Agassandian, Lei, Shi, Dwight C, Look, Rama K, Mallampalli   +4 more
openaire   +2 more sources