Results 141 to 150 of about 24,839 (187)

Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome. [PDF]

Int J Mol Med
Zhai J, Zhang Y, Gong J, Fu L, Zhang S.
europepmc   +1 more source

Ecotoxicity of Nitrated Monoaromatic Hydrocarbons in Aquatic Systems: Emerging Risks from Atmospheric Deposition of Biomass Burning and Anthropogenic Aerosols. [PDF]

Toxics
Bakija Alempijević S, Strmečki S, Mihaljević I, Frka S, Dragojević J, Jakovljević I, Smital T.   +6 more
europepmc   +1 more source

Metformin-Associated Gastrointestinal Intolerance: A Narrative Review of Mechanisms and Clinical Management. [PDF]

Clin Med Insights Endocrinol Diabetes
Chen S, Xu B, Lu M.
europepmc   +1 more source

NAMs for closing knowledge gaps in assessment of respiratory uptake - a PARC project. [PDF]

Front Toxicol
Billat PA, Hansen T, De Bruijn V, Boufalaas R, Stefano S, Sosnowska A, Kohl Y, Verstraelen S, Camassa LMA, Spänig M, Gabriel C, Sarigiannis D, Krätschmer K, Raitano G, Bulawska N, Ratier A, Zienolddiny-Narui S, Chary A, Serchi T, Viegas S, Mollerup S, Escher SE, Staal YCM.   +22 more
europepmc   +1 more source

Color-tunable luminescent Tb_xEu_y(BDC) complexes assembled within liposome-based nanoreactors.

Cell Rep Phys Sci
Torres-Huerta A, de J Velásquez-Hernández M, Lempereur S, Troian-Gautier L, Veronesi G, Valkenier H.   +5 more
europepmc   +1 more source

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Functional Characteristics and Tissue Distribution Pattern of Organic Cation Transporter 2 (OCTN2), an Organic Cation/Carnitine Transporter

Journal of Pharmacology and Experimental Therapeutics, 1999
We have demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a transporter for organic cations as well as carnitine. OCTN2 transports organic cations without involving Na(+), but it transports carnitine only in the presence of Na(+).
Xiang Wu, Puttur D Prasad, Frederick H Leibach   +2 more
exaly   +3 more sources

Thiamine is a substrate of organic cation transporters in Caco-2 cells

European Journal of Pharmacology, 2012
The aim of this study was to characterize the intestinal absorption of thiamine, by investigating the hypothesis of an involvement of Organic Cation Transporter (OCT) family members in this process. [(3)H]-T(+) uptake was found to be: 1) time-dependent, 2) Na(+)- and Cl(-)-dependent, 3) pH-dependent, with uptake increasing with a decrease in ...
Clara Lemos, Ana Faria, Manuela Meireles, Fatima Martel, Rosario Monteiro, Conceicao Calhau   +5 more
openaire   +3 more sources

Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

Clinical Pharmacology & Therapeutics, 2008
Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared ...
I S, Song, H J, Shin, E J, Shim, I S, Jung, W Y, Kim, J H, Shon, J G, Shin   +6 more
openaire   +2 more sources

3D-QSAR analysis of the interactions of flavonoids with human organic cation transporter 2

Toxicology Letters, 2022
Flavonoids are a class of phenolic and polyphenolic compounds widely distributed in vegetables, fruits, grains and herbs. Organic cation transporter 2 (OCT2) mediates the renal secretion of organic cations and is a key site of drug-drug interactions (DDIs).
Yajuan, Bi, Xue, Wang, Huixiang, Li, Yiqing, Tian, Lifeng, Han, Chunshan, Gui, Youcai, Zhang   +6 more
openaire   +2 more sources

Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport Efficiency

2006
The extraneuronal monoamine transporter (EMT) corresponds to the classical steroid-sensitive monoamine transport mechanism that was first described as "uptake2" in rat heart with noradrenaline as substrate. The organic cation transporters OCT1 and OCT2 are related to EMT. The three carriers share basic structural and functional characteristics.
E, Schömig, A, Lazar, D, Gründemann
openaire   +2 more sources