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Characterization of the Basal Promoter Element of Human Organic Cation Transporter 2 Gene
The Journal of Pharmacology and Experimental Therapeutics, 2007Human organic cation transporter 2 (hOCT2; SLC22A2) is abundantly expressed in the kidney, and it plays important roles in the renal tubular secretion of cationic drugs. Although the transport characteristics of hOCT2 have been studied extensively, there is no information available for the transcriptional regulation of hOCT2.
Jun-ichi, Asaka +4 more
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Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity
2009Cisplatin is an effective but highly nephrotoxic antineoplastic agent. Though many aspects of cisplatin interactions with DNA and cellular proteins are well described, specific systems for cisplatin transport across the cell membrane have only recently been identified. In this paper our findings on this topic are illustrated and reviewed in relation to
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Chemico-Biological Interactions
Niclosamide is an anthelmintic drug with a long history of use and is generally safe and well tolerated in humans. As the conventional dose of niclosamide results in a low but certain level in systemic circulation, drug interactions with concomitant drugs should be considered.
Min-Ji Kang +5 more
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Niclosamide is an anthelmintic drug with a long history of use and is generally safe and well tolerated in humans. As the conventional dose of niclosamide results in a low but certain level in systemic circulation, drug interactions with concomitant drugs should be considered.
Min-Ji Kang +5 more
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[Advances in the study of regulation of novel organic cation transporter-2].
Yao xue xue bao = Acta pharmaceutica Sinica, 2012Novel organic cation transporter-2 (OCTN2), a member of the organic cation transporter family, may transport carnitine and multiple organic cationic drugs. Thus OCTN2 possesses substantial roles in physiology and pharmacology. A number of researches have proven that many factors can regulate the expression and/or function of OCTN2 via different ...
Fu-Rong, Wang, Rui-Chen, Guo
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Organic cation transporter 2 (OCT2) is implicated in the response to stress
2012no ...
Giros, B. +5 more
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OCT-2, Organic Cation Transporter 2
2007Valentin Gorboulev, Hermann Koepsell
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OCTN-2, Organic Cation-Sodium Transporter 2
2007Valentin Gorboulev, Hermann Koepsell
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Cloning and Functional Expression of a Human Liver Organic Cation Transporter
Molecular Pharmacology, 1997Mark J Dresser +2 more
exaly