Putative new biomarkers for renal transporter-mediated drug-drug interactions: Characterization as substrates of organic cation transporter 2, multidrug and toxin extrusion protein 1, and other important drug transporters. [PDF]
Drug Metab DisposGessner A +5 more
europepmc +1 more source
Adaptive Hydrogels With Spatiotemporal Stiffening Using pH‐Modulating Enzymes
Advanced Functional Materials, EarlyView.The chemomechanical coupling in an adaptive hydrogel is studied to further the development of adaptive hydrogels. This coupling is achieved by embedding a pH‐modulating enzyme in a pH‐responsive hydrogel. The enzymatic reaction can be triggered locally, which generates a pH‐decreasing wave throughout the system, increasing the crosslinking density and ...
Natascha Gray +3 more
wiley +1 more source
Development of Immobilised Biopolymer Stationary Phases based on the Efflux Transporters [PDF]
The body is continuously exposed to a variety of toxins and metabolic waste products but is able to rid itself of these by using various detoxification mechanisms such as enzymes and transmembrane transporters.
Patel, Sharvil Pankaj
core
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Advanced Functional Materials, EarlyView.A soft, dual‐channel hydrogel patch enables simultaneous detection of wound temperature and strain by integrating ion‐diffusion‐mediated thermoelectric and resistive sensing. The conformal design maintains stable performance during motion, capturing subtle inflammatory and mechanical changes for continuous wound monitoring.
Yu Fang +7 more
wiley +1 more source
Effects of Cimetidine and Dolutegravir on the Endogenous Drug-Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers. [PDF]
Clin Pharmacol TherKoishikawa T +17 more
europepmc +1 more source
Lansoprazole suppresses cisplatin-induced ototoxicity via inhibiting organic cation transporter 2
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022 Wakai Eri +3 more
openaire +1 more source
LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models
Advanced Functional Materials, EarlyView.This work establishes oligolamellar bacterial membrane models to investigate how LL‐37 disrupts the complex dual‐bilayer architecture of Gram‐negative bacteria. Combining SAXS, cryo‐TEM, electrophoretic mobility measurements, and coarse‐grained simulations, it reveals cardiolipin‐driven phase transitions leading to bicelle‐like structures and membrane ...
Bettina Tran +5 more
wiley +1 more source
Modulating the Activity of the Human Organic Cation Transporter 2 Emerges as a Potential Strategy to Mitigate Unwanted Toxicities Associated with Cisplatin Chemotherapy. [PDF]
Int J Mol SciHucke A +6 more
europepmc +1 more source
Potent inhibition of human organic cation transporter 2 (hOCT2) by β-carboline alkaloids. [PDF]
Xenobiotica, 2017 Wagner DJ +4 more
europepmc +1 more source