Results 121 to 130 of about 110,333 (306)

Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride

Journal of Pharmaceutical Analysis
Evaluating toxicity and decoding the underlying mechanisms of active compounds are crucial for drug development. In this study, we present an innovative, integrated approach that combines air flow-assisted desorption electrospray ionization mass ...
Shu Yang, Zhonghua Wang, Yanhua Liu, Xin Zhang, Hang Zhang, Zhaoying Wang, Zhi Zhou, Zeper Abliz   +7 more
doaj   +1 more source

Anion‐Exchange‐Enabled Hydrogel Electrolytes With High Zn2+ Transference for Dendrite‐Free Flexible Zinc‐Ion Batteries

Advanced Functional Materials, EarlyView.
A high‐Zn2+‐transference hydrogel electrolyte of ex‐PDADAM is developed via anion exchange at quaternary ammonium sites, achieving high Zn2+ transference number (0.86), ionic conductivity (8.10 mS cm−1), and toughness (51.25 MJ m−3). Symmetric cells are operated stably for over 2000 h, while flexible pouch cells retain 90.9% capacity after 300 cycles ...
Jung Woo Hong, Yeon Su Kim, Zuyang Hu, Hyungyu Cho, Gun Jang, Minjun Hwang, Hye Rin Park, Jun Su Kim, Ho Seok Park   +8 more
wiley   +1 more source

Atomized Oxidative Polymerization as a 3D Printing Platform for Binder‐Free, Bulk Conductive Polymer Architectures

Advanced Functional Materials, EarlyView.
Co‐delivery of electrosprayed EDOT and oxidant enables bulk oxidative polymerization during layer‐by‐layer fabrication, creating stable, highly conductive 3D PEDOT structures. This Atomized Oxidative Polymerization (AOP) overcomes the surface deposition‐only and matrix‐limited conductivity of conventional Vapor Phase Polymerization (VPP) and PEDOT:PSS ...
Tazdik Patwary Plateau, Hiep Pham, Jonghyun Park   +2 more
wiley   +1 more source

Organic Cation Transporters and their Pharmacokinetic and Pharmacodynamic Consequences

Drug Metabolism and Pharmacokinetics, 2008
To clarify the considerable interindividual variability in the pharmacokinetics, efficacy, and toxicity of drugs, genetic polymorphism of drug transporters has attracted interest because these transporters play important roles in the gastrointestinal absorption, biliary and renal elimination, and distribution to target sites of their substrates. Of the
CHOI, Min-Koo, SONG, Im-Sook
openaire   +2 more sources

Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance

BMC Cancer, 2012
Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics.
M. Heise, A. Lautem, J. Knapstein, J. Schattenberg, M. Hoppe-Lotichius, D. Foltys, N. Weiler, A. Zimmermann, A. Schad, D. Gründemann, G. Otto, P. Galle, M. Schuchmann, T. Zimmermann   +13 more
semanticscholar   +1 more source

Polymer‐Redox Interactions Enhance Ferro/Ferricyanide Thermogalvanic Cells

Advanced Functional Materials, EarlyView.
Polyelectrolyte could modify the hydration structure of the redox couple in solution and improve the output performance of thermogalvanic cells, providing new fundamental insight into how electrostatic interactions can be exploited to tailor thermoelectric properties.
Pedro Santos Candiotto de Oliveira, Ziyauddin Khan, Swathi Suneesh, Sarbani Ghosh, Zia Ullah Khan, Reverant Crispin, Dan Zhao   +6 more
wiley   +1 more source

Preparation and Evaluation of New Ligands Targeting Organic Cation Transporters in the Central Nervous System for the Treatment of Depression

, 2021
Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Student: Andrea Monteiro Supervisor: Assoc. Prof. PharmDr. Jaroslav Roh, Ph.D. Specialized supervisors: Nicolas Pietrancosta, Ph.D. Sophie Gautron, Ph.
Monteiro, Andrea
core  

Sustainable Electrochemical Synthesis of High‐Quality MXenes: Mechanistic Insights, Applications, Challenges, and Technological Prospects

Advanced Functional Materials, EarlyView.
Electrochemical etching provides an eco‐friendly alternative to hazardous HF methods for MXene production. This approach facilitates the selective isolation of the A‐layer from MAX phases with tunable surface terminations. Controlling voltage, electrolytes, temperature, and duration enables the optimal structural integrity. Nevertheless, existing scale
Jagdeep Singh, Madhusudhana M Devadiga, Santosh K. Tiwari, AS Dhaliwal, Gurpreet Singh Selopal   +4 more
wiley   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source