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Organic Cation Transporters in Brain Catecholamine Homeostasis
Handbook of Experimental Pharmacology, 2021 Catecholamines, including dopamine, norepinephrine, and epinephrine, are modulatory transmitters released from specialized neurons throughout the brain. Collectively, catecholamines exert powerful regulation of mood, motivation, arousal, and plasticity.
P. Gasser
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Structural modeling of human organic cation transporters
Computational Biology and Chemistry, 2017Human organic cation transporters (hOCTs) belong to solute carriers (SLC) 22 family of membrane proteins that play a central role in transportation of chemotherapeutic drugs for several clinical and pathological conditions, including cancer and diabetes.
Tikam Chand Dakal +2 more
exaly +4 more sources
Xenobiotica, 2008
1. Organic cation transporters (OCTs) translocate endogenous (e.g. dopamine) and exogenous (e.g. drugs) substances of cationic nature and, therefore, play an important role in the detoxification of exogenous compounds. This review aims to furnish essential information on OCTs, with an emphasis on pharmacological aspects. 2.
G Ciarimboli
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1. Organic cation transporters (OCTs) translocate endogenous (e.g. dopamine) and exogenous (e.g. drugs) substances of cationic nature and, therefore, play an important role in the detoxification of exogenous compounds. This review aims to furnish essential information on OCTs, with an emphasis on pharmacological aspects. 2.
G Ciarimboli
exaly +3 more sources
The Journal of Pharmacology and Experimental Therapeutics, 2001 Previous inhibition studies with taurocholate and cardiac glycosides suggested the presence of separate uptake systems for small "type I" (system1) and for bulky "type II" (system2) organic cations in rat hepatocytes. To identify the transport systems involved in type I and type II organic cation uptake, we compared the organic cation transport ...
van Montfoort, J. E. +5 more
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Genetic and Epigenetic Regulation of Organic Cation Transporters
Handbook of Experimental Pharmacology, 2021Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 are the subject of intensive research because they mediate the transport of many clinically-relevant drugs such as the antidiabetic agent metformin, the opioid tramadol, and the antimigraine agent sumatriptan.
Charlotte, Kölz +3 more
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Substrate recognition and translocation by polyspecific organic cation transporters
Biological Chemistry, 2011 Organic cation transporters (OCTs) of the SLC22 family play a pivotal role in distribution and excretion of cationic drugs. They mediate electrogenic translocation of cations in both directions. OCTs are polyspecific transporters.
Hermann Koepsell
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Regulation of organic cation transport
Pfl�gers Archiv - European Journal of Physiology, 2004Transport of organic cations (OC) is important for the recycling of endogenous OC and also a necessary step for detoxification of exogenous OC in the body. Even though the identification and characterisation of numerous OC transporters in recent years has allowed the elucidation of molecular mechanisms underlying OC transport, elucidation of the ...
Giuliano, Ciarimboli +1 more
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Role of organic cation transporters in drug–drug interaction
Expert Opinion on Drug Metabolism and Toxicology, 2015Hermann Koepsell
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2003
Over the last 15 years, a number of transporters that translocate organic cations were characterized functionally and also identified on the molecular level. Organic cations include endogenous compounds such as monoamine neurotransmitters, choline, and coenzymes, but also numerous drugs and xenobiotics.
H, Koepsell, B M, Schmitt, V, Gorboulev
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Over the last 15 years, a number of transporters that translocate organic cations were characterized functionally and also identified on the molecular level. Organic cations include endogenous compounds such as monoamine neurotransmitters, choline, and coenzymes, but also numerous drugs and xenobiotics.
H, Koepsell, B M, Schmitt, V, Gorboulev
openaire +2 more sources