Results 271 to 280 of about 110,333 (306)

Molecular Pharmacology of Organic Cation Transporters in Kidney

Journal of Membrane Biology, 1999
The homeostasis of endogenous organic cations, such as choline and N P-methylnicotinamide, monoamine neurotransmitters, cationic drugs, such as cimetidine, morphine, quinine and amantadine, and of cationic xenobiotics is controlled by reabsorption and excretion in the small intestine, by metabolic conversion and excretion in the liver, and by ...
H, Koepsell, V, Gorboulev, P, Arndt
openaire   +2 more sources

Substrates and Inhibitors of Organic Cation Transporters (OCTs) and Plasma Membrane Monoamine Transporter (PMAT) and Therapeutic Implications.

Handbook of Experimental Pharmacology, 2021
H. Bönisch
semanticscholar   +1 more source

Organic Cation Transporter Expression and Function in the CNS

2021
The blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) represent major control checkpoints protecting the CNS, by exerting selective control over the movement of organic cations and anions into and out of the CNS compartment. In addition, multiple CNS cell types, e.g., astrocytes, ependymal cells, microglia, contribute to processes
openaire   +2 more sources

Interaction of pharmaceutical excipients with organic cation transporters

International Journal of Pharmaceutics, 2017
Increasing evidences have shown that many pharmaceutical excipients are not pharmacologically inert but instead have effects on several transport function of uptake and efflux drug transporters. Herein, we investigated whether the excipients frequently used in many drug formulations affect transport function of organic cation transporters (OCTs) that ...
Sirima, Soodvilai, Sunhapas, Soodvilai, Varanuj, Chatsudthipong, Tanasait, Ngawhirunpat, Theerasak, Rojanarata, Praneet, Opanasopit   +5 more
openaire   +2 more sources

The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances.

Handbook of Experimental Pharmacology, 2021
Julian Maier, M. Niello, Deborah Rudin, L. Daws, H. Sitte   +4 more
semanticscholar   +1 more source

Organic Cation Transporters

2021
Alan Talevi, Carolina L. Bellera
openaire   +1 more source

Genetic variation in organic cation transporters and considerations in drug development

Expert Opinion on Drug Metabolism and Toxicology, 2023
Manthena V S Varma
exaly  

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide.

Journal of Pharmacy and Science, 2017
T. Miyake, T. Mizuno, Tatsuki Mochizuki, M. Kimura, S. Matsuki, S. Irie, I. Ieiri, K. Maeda, H. Kusuhara   +8 more
semanticscholar   +1 more source

Effects of frequently used pharmaceutical excipients on the organic cation transporters 1–3 and peptide transporters 1/2 stably expressed in MDCKII cells

European journal of pharmaceutics and biopharmaceutics, 2017
Marcus Otter, S. Oswald, W. Siegmund, M. Keiser   +3 more
semanticscholar   +1 more source

Multiple organic cation transporters contribute to the renal transport of sulpiride

Biopharmaceutics & drug disposition, 2017
Li-ping Li, Y. Weng, Wei Wang, Mengru Bai, H. Lei, Hui Zhou, Huidi Jiang   +6 more
semanticscholar   +1 more source