Results 261 to 270 of about 110,333 (306)

Stereoselective Interactions of Organic Cations with the Organic Cation Transporter in OK Cells

Pharmaceutical Research, 1993
Recent studies have suggested that certain organic cations, such as pindolol and the diastereomers, quinine and quinidine, may be stereoselectively secreted by the kidney in humans. The goal of this study was to determine if the enantiomers of pindolol, verapamil, and disopyramide and the diastereomers, quinine and quinidine, interact stereoselectively
R J, Ott, K M, Giacomini
openaire   +2 more sources

Elucidation of N1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters

Drug Metabolism And Disposition, 2019
Endogenous substrates are emerging biomarkers for drug transporters, which serve as surrogate probes in drug-drug interaction (DDI) studies. In this study, the results of metabolome analysis using wild-type and Oct1/2 double knockout mice suggested that ...
T. Miyake, T. Mizuno, Issey Takehara, Tatsuki Mochizuki, M. Kimura, S. Matsuki, S. Irie, Nobuaki Watanabe, Y. Kato, I. Ieiri, K. Maeda, O. Ando, H. Kusuhara   +12 more
semanticscholar   +1 more source

Renal organic cation and nucleoside transport

Biochemical Pharmacology, 2002
We previously reported that the rat organic cation transporter rOCT1 could transport the nucleoside analog deoxytubercidin (dTub) (Chen R, Nelson JA. Biochem Pharmacol 2000;60:215-9). The cationic form of dTub (dTub(+)) appeared to be the true substrate of rOCT1. We also reported that although rOCT2 is similar to rOCT1, it does not transport dTub at pH
Chen, R, Jonker, JW, Nelson, JA
openaire   +3 more sources

Renal Transport of Organic Anions and Cations

Comprehensive Physiology, 2011
Abstract Organic anions and cations (OAs and OCs, respectively) comprise an extraordinarily diverse array of compounds of physiological, pharmacological, and toxicological importance. The kidney, primarily the renal proximal tubule, plays a critical role in regulating the plasma concentrations of these organic ...
Ryan M, Pelis, Stephen H, Wright
openaire   +2 more sources

Organic Cation Transporters

Cambridge International Law Journal, 2016
S. Gautron, E. Schlatter
openaire   +2 more sources

Transport of small organic cations in the rat liver

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996
The kidneys and the liver are the principal organs for the inactivation of circulating organic cations. Recently, an organic cation transporter (OCT1) has been cloned from rat kidney. In order to answer the question whether OCT1 is involved also in hepatic uptake of organic cations, the pharmacological characteristics of organic cation transport in ...
F, Martel, T, Vetter, H, Russ, D, Gründemann, I, Azevedo, H, Koepsell, E, Schömig   +6 more
openaire   +2 more sources

Are organic cation transporters capable of transporting prostaglandins?

Naunyn-Schmiedeberg's Archives of Pharmacology, 2005
The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.
Stephanie, Harlfinger, Christian, Fork, Andreas, Lazar, Edgar, Schömig, Dirk, Gründemann   +4 more
openaire   +2 more sources

Organic Cation Transporters and Nongenomic Glucocorticoid Action

2021
Corticosteroid hormones exert powerful influences on neuronal physiology and behavior by activating intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), which act as ligand-gated transcription factors, altering gene expression.
Benton, Kelsey C., Lowry, Christopher A., Gasser, Paul J.   +2 more
openaire   +3 more sources

Regulation of the human organic cation transporter hOCT1

Journal of Cellular Physiology, 2004
AbstractThe human organic cation transporter type 1 (hOCT1) is an important transport system for small organic cations in the liver. Organic cation transporters are regulated by different signaling pathways, but the regulation of hOCT1 has not yet been studied. In this work, we have for the first time investigated the regulation of hOCT1.
Giuliano, Ciarimboli, Katja, Struwe, Petra, Arndt, Valentin, Gorboulev, Hermann, Koepsell, Eberhard, Schlatter, Jochen R, Hirsch   +6 more
openaire   +2 more sources

Structure and Function of Renal Organic Cation Transporters

Physiology, 1998
Polyspecific transport systems in the kidney mediate the excretion and reabsorption of organic cations. Electrogenic import systems and electroneutral export systems in the basolateral and luminal plasma membranes of proximal renal tubules are involved.
Hermann, Koepsell, Andreas, Busch, Valentin, Gorboulev, Petra, Arndt   +3 more
openaire   +2 more sources