Results 51 to 60 of about 110,333 (306)

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. [PDF]

Sci Rep, 2016
The type-2 diabetes drug metformin has proven to have protective effects in several renal disease models. Here, we investigated the protective effects in a 3-day unilateral ureteral obstruction (3dUUO) mouse model.
Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R, Nørregaard R.   +11 more
europepmc   +2 more sources

The NorM MATE transporter from N. gonorrhoeae: insights into drug and ion Binding from atomistic molecular dynamics simulations

, 2014
The multidrug and toxic compound extrusion transporters extrude a wide variety of substrates out of both mammalian and bacterial cells via the electrochemical gradient of protons and cations across the membrane.
Khalid, Syma, Syma Khalid, Leung, Yuk Ming, Yuk Ming Leung, Holdbrook, Daniel A., Thomas J. Piggot, Piggot, Thomas J., Daniel A. Holdbrook   +7 more
core   +1 more source

Multiple binding sites in organic cation transporters require sophisticated procedures to identify interactions of novel drugs

Biological chemistry, 2018
In vitro evaluation of drugs for interaction with transporters is essential during drug development. As polyspecific organic cation transporters (OCTs) are critical for pharmacokinetics of many cationic drugs, in vitro testing of human OCT1 and human ...
H. Koepsell
semanticscholar   +1 more source

Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models

Cells
The polarised expression of specific transporters in proximal tubular epithelial cells is important for the renal clearance of many endogenous and exogenous compounds.
Tamara Meijer, Daniel da Costa Pereira, Olivia C. Klatt, Joanne Buitenhuis, Paul Jennings, Anja Wilmes   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural basis of organic cation transporter-3 inhibition

bioRxiv, 2022
Organic cation transporters (OCTs) facilitate the translocation of catecholamines and xenobiotics across the plasma membrane in various tissues throughout the human body.
Basavraj Khanppnavar, Julian Maier, Freja Herborg, R. Gradisch, Erika Lazzarin, D. Luethi, Jae-Won Yang, Chao Qi, M. Holy, Kathrin Jäntsch, O. Kudlacek, K. Schicker, T. Werge, U. Gether, T. Stockner, V. Korkhov, H. Sitte   +16 more
semanticscholar   +1 more source

Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke

Journal of Central Nervous System Disease, 2017
Ischemic stroke is a leading cause of morbidity and mortality in the United States. The only approved pharmacologic treatment for ischemic stroke is thrombolysis via recombinant tissue plasminogen activator (r-tPA). A short therapeutic window and serious
Hrvoje Brzica, Wazir Abdullahi, Kathryn Ibbotson, Patrick T Ronaldson   +3 more
doaj   +1 more source

Cadmium Uptake by Wheat (Triticum aestivum L.): An Overview

Plants, 2020
Cadmium is a toxic heavy metal that may be detected in soils and plants. Wheat, as a food consumed by 60% of the world’s population, may uptake a high quantity of Cd through its roots and translocate Cd to the shoots and grains thus posing risks to human
Tayebeh Abedi, Amin Mojiri
doaj   +1 more source

Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters

Pharmaceutics, 2021
Remdesivir has been approved for treatment of COVID-19 and shortens the time to recovery in hospitalized patients. Drug transporters removing remdesivir from the circulation may reduce efficacy of treatment by lowering its plasma levels.
Anne T. Nies, Jörg König, Ute Hofmann, Charlotte Kölz, Martin F. Fromm, Matthias Schwab   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source