Results 61 to 70 of about 284,111 (305)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Bioaccumulation and Toxicity of Organic Chemicals in Terrestrial Invertebrates [PDF]

, 2020
Terrestrial invertebrates are key components in ecosystems, with crucial roles in soil structure, functioning, and ecosystem services. The present chapter covers how terrestrial invertebrates are impacted by organic chemicals, focusing on up-to-date ...
van Gestel, Cornelis A.M.; id_orcid, Diogo N. Cardoso, Susana Loureiro, Morgado, Rui G., Rui G. Morgado, Prodana, Marija, Ortega-Calvo, Jose Julio, Cornelis A. M. van Gestel, Parsons, John Robert, Catarina Malheiro, M. Nazaret González-Alcaraz, Cardoso, Diogo N., González-Alcaraz, M. Nazaret, van Gestel, Cornelis A.M., Loureiro, Susana, Marija Prodana, Malheiro, Catarina   +16 more
core   +1 more source

Role of support composition in controlling small diameter carbon nanotube synthesis over Co/Al2O3–MgO catalyst

Discover Chemistry
Small diameter carbon nanotubes are anticipated to be applied across numerous fields, including safety and energy technologies, due to their superior physical properties.
Jinjin Jiang, Liusi Yu, Haiwen Tang, Honglin Yu, Min Zhou, Wenjing Liu, Xinxiu Yan   +6 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Successfull Blossom Thinning and Crop Load Regulation for Organic Apple Growing with Potassium-bi-carbonate (Armicarb(R)): Results of Field Experiments over 3 Years and with 11 Cultivars

, 2012
With field trials over 3 years in a commercial organic orchard in Switzerland we have tested the efficacy of Armicarb® (potassium-bi-carbonate) for flower thinning in organic apple production.
Monzelio, U., Weibel, Franco P., Giordano, I., Weibel, F. P., Lemcke, B., Kloss, B.   +5 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Industrial Organic Chemicals. Starting Materials and Intermediates

Molecules, 1999
n ...
Shu-Kun Lin
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source