Results 81 to 90 of about 494,571 (318)

The turnover of organic matter in soil [PDF]

open access: yesBiochemical Journal, 1968
There is little quantitative data on the turnover of soil organic matter even for parts of the world where long-term field experiments have been carried out. Comparisons of turnover under different climatic conditions, under different systems of agriculture, under different plant associations, at different pH's, in soils differing mechanical ...
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Clay-associated organic matter in kaolinitic and smectitic soils

open access: yes, 2002
The primary source of soil organic matter is plant debris of all kinds, such as dead roots, leaves and branches that enter into the soil and are then biologically decomposed at variable rates.
Wattel-Koekkoek, E.J.W.
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Biomimetic Dehydrogenative Intermolecular Formal Allylic Amidation of Branched α‐Olefins

open access: yesAdvanced Science
Allylic amide moieties are commonly encountered in natural products and are privileged structures in pharmaceuticals and agrochemicals. Moreover, because allylic amide can be to converted into an array of high‐value motifs, they have been widely employed
Xiaoyang Fu   +6 more
doaj   +1 more source

Pan-arctic trends in terrestrial dissolved organic matter from optical measurements

open access: yes, 2016
Climate change is causing extensive warming across arctic regions resulting in permafrost degradation, alterations to regional hydrology, and shifting amounts and composition of dissolved organic matter (DOM) transported by streams and rivers.
Tank, Suzanne   +38 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Natural sulfurization of carbohydrates in marine sediments : consequences for the chemical and carbon isotopic composition of sedimentary organic matter

open access: yes, 2003
Carbohydrates make up the largest part of the organic matter in the biosphere and are used by living organism for many different reasons. They serve, among others, as carbon and energy source as well as metabolic intermediates.
Organic geochemistry & molecular biogeology   +6 more
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

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