Results 91 to 100 of about 5,589,379 (336)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Discovery and molecular docking studies of nitrogen containing naphthyridine derivatives as potent HIV1 NNRTIs with anticancer potential

Scientific Reports
Fourteen novel 2,4-disubstituted-1,6- and 1,7-naphthyridine derivatives were developed to enhance HIV-1 RT inhibition through molecular hybridization of NNRTIs.
Apisara Baicharoen, Pongsit Vijitphan, Suwicha Patnin, Nanthawan Reukngam, Panita Khlaychan, Mayuso Kuno, Apinya Chaivisuthangkura, Supanna Techasakul, Arthit Makarasen   +8 more
doaj   +1 more source

A Facile One-Pot Approach to the Synthesis of Gd-Eu Based Metal-Organic Frameworks and Applications to Sensing of Fe3+ and Cr2O72− Ions [PDF]

, 2021
Roberta Puglisi, Anna Lucia Pellegrino, Roberto Fiorenza, Salvatore Scirè, Graziella Malandrino   +4 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Crystal structure of 3-amino-5,5-dimethyl-2-[(E)-2-nitroethenyl]cyclohex-2-en-1-one

Acta Crystallographica Section E, 2014
The asymmetric unit of the title compound, C10H14N2O3, contains two independent molecules with similar conformations. In the both molecules, the cyclohexene rings adopt the same envelope conformation with the flap C atoms lying 0.658 (3) and 0.668 (3) Å ...
Brigita Vigante, Dmitrijs Stepanovs, Andrejs Pelss, Anatoly Mishnev   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Bis-DCM Type Dyes: Convenient Method for Synthesis of 2-(2, 6-bis(4-(dialkylamino)styryl)-4H -pyran-4-ylidene) Malononitrile Derivatives [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2018
An efficient and convenient method for synthesis of 2,6-bis (4-(dialkylamino) styryl)-4H-pyran-4-one starting from 4- (dialkylamino) benzaldehyde with 2,6-dimethyl-4H-pyran-4-onein the presence of MeONa as the base was described.
Reza Teimuri-Mofrad, Negar Boroomand, Keshvar Rahimpour, Raha Hadi, Ahmad Poursadegh   +4 more
doaj  

Microwave-assisted organic synthesis, antimycobacterial activity, structure–activity relationship and molecular docking studies of some novel indole-oxadiazole hybrids

, 2022
Nisheeth C. Desai, Hardik Somani, Harsh K. Mehta, Dharmpalsinh J. Jadeja, Ashvinkumar G. Khasiya, Vijay M. Khedkar   +5 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Visible Light-induced Palladium-catalysis in Organic Synthesis

Chemistry Letters, 2019
Palladium-catalyzed carbon-carbon and carbon-heteroatom bond construction are among the most significant and powerful methods in organic synthesis.
Wen-Jun Zhou, Guang‐Mei Cao, Zhanjin Zhang, Da‐Gang Yu   +3 more
semanticscholar   +1 more source